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Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure
文献类型：期刊论文
| 作者 | He, Jing1; Tsai, Louis M.2; Leong, Yew Ann2; Hu, Xin2,3; Ma, Cindy S.4,5; Chevalier, Nina4,5,6; Sun, Xiaolin1; Vandenberg, Kirsten7; Rockman, Steve7; Ding, Yan1 |
| 刊名 | IMMUNITY
 |
| 出版日期 | 2013-10-17 |
| 卷号 | 39期号:4页码:770-781 |
| ISSN号 | 1074-7613 |
| 英文摘要 | Follicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5(+) CD4(+) T cells in humans and mice, the CCR7(lo)PD-1(hi) subset has a partial Tfh effector phenotype, whereas CCR7(hi) PD-1(lo) cells have a resting phenotype. The circulating CCR7(lo)PD-1(hi) subset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7(lo)PD-1(hi) subset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7(hi)PD-1(lo) and CCR7(lo)PD-1(hi) subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5(+) helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7(lo)PD-1(hi) CXCR5(+) precursors rapidly differentiate into mature Tfh cells to promote anti-body responses. Therefore, circulating CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology |
| 研究领域[WOS] | Immunology |
| 关键词[WOS] | FOLLICULAR HELPER-CELL ; CENTER B-CELL ; CXC CHEMOKINE RECEPTOR-5 ; SYSTEMIC AUTOIMMUNITY ; BCL6 EXPRESSION ; CENTRAL MEMORY ; HIV-INFECTION ; EFFECTOR ; DIFFERENTIATION ; GENERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330950000017 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/13373]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China 2.Monash Univ, Sch Biomed Sci, Mol Immunomodulat Lab, Clayton, Vic 3800, Australia 3.Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia 4.Garvan Inst Med Res, Program Immunol, Darlinghurst, NSW 2010, Australia 5.Univ New S Wales, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia 6.Univ Med Ctr Freiburg, Dept Rheumatol & Clin Immunol, D-79106 Freiburg, Germany 7.BioCSL, Influenza Res & Dev, Parkville, Vic 3052, Australia 8.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 9.Shandong Acad Sci, Shandong Anal & Test Ctr, Lab Immunol Environm & Hlth, Jinan 250014, Shandong, Peoples R China 10.Walter & Eliza Hall Inst Med Res, Div Mol Immunol, Parkville, Vic 3052, Australia |
| 推荐引用方式 GB/T 7714 | He, Jing,Tsai, Louis M.,Leong, Yew Ann,et al. Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure[J]. IMMUNITY,2013,39(4):770-781. |
| APA | He, Jing.,Tsai, Louis M..,Leong, Yew Ann.,Hu, Xin.,Ma, Cindy S..,...&Yu, Di.(2013).Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure.IMMUNITY,39(4),770-781. |
| MLA | He, Jing,et al."Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure".IMMUNITY 39.4(2013):770-781. |
入库方式： OAI收割
来源：过程工程研究所
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