Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps
文献类型：期刊论文
| 作者 | Ku, Zhiqiang1; Ye, Xiaohua1; Huang, Xulin1; Cai, Yicun1; Liu, Qingwei1; Li, Yan2; Su, Zhiguo2; Huang, Zhong1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013-02-22 |
| 卷号 | 8期号:2页码:57601 |
| 英文摘要 | Background: Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease, which has been prevalent in Asia-Pacific regions, causing significant morbidity and mortality in young children. Antibodies elicited by experimental EV71 vaccines could neutralize infection in vitro and passively protect animal models from lethal challenge, indicating that neutralizing antibodies play an essential role in protection. However, how neutralizing antibodies inhibit infection in vitro remains unclear. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | MOUTH-DISEASE ; VP1 PROTEIN ; MICE ; HAND ; IMMUNIZATION ; VACCINE ; LETHAL ; IDENTIFICATION ; CHALLENGE ; OUTBREAK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000316658800113 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/13383]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol Virol & Immunol, Inst Pasteur Shanghai, Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ku, Zhiqiang,Ye, Xiaohua,Huang, Xulin,et al. Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps[J]. PLOS ONE,2013,8(2):57601. |
| APA | Ku, Zhiqiang.,Ye, Xiaohua.,Huang, Xulin.,Cai, Yicun.,Liu, Qingwei.,...&Huang, Zhong.(2013).Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps.PLOS ONE,8(2),57601. |
| MLA | Ku, Zhiqiang,et al."Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps".PLOS ONE 8.2(2013):57601. |
入库方式： OAI收割
来源：过程工程研究所
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