Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs
文献类型：期刊论文
| 作者 | Yue, Zhanguo1,2; You, Zuoxiang1,3; Yang, Qinzheng3; Lv, Piping1,2; Yue, Hua1; Wang, Bin1; Ni, Dezhi1,2; Su, Zhiguo1; Wei, Wei1; Ma, Guanghui1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:26页码:3239-3247 |
| ISSN号 | 2050-750X |
| 英文摘要 | Various carriers are being advanced for anti-cancer therapy, which can protect drugs and ferry them to the target site. However, little understanding exists regarding the effect of molecular structure on anti-cancer drug delivery efficiency. To fill this knowledge gap, we take poly(lactic acid) (PLA), poly(lactide-co-glycolide) (PLGA), and poly-ethylene glycol-co-poly-lactide (PEG-b-PLA) polymers as prototype materials and comparatively explore the inherent relationship between the molecular structure and the delivery ability. Compared with PLA and PLGA NPs, PEG-b-PLA ones possess the advantages of longer blood circulation time, more tumor accumulation, and better intratumoral delivery ability. Subsequent mechanism investigations reveal that the molecular structure will regulate the polymer arrangement and render NPs different hydrophilicity/deformability, which dictate the distinct delivery performances. Finally, the superior PEG-b-PLA NPs are further loaded with the anti-cancer drug paclitaxel (PTX) and functionalized with magnetic (M) Fe3O4 nanocrystals. As-designed PTX/M PEG-b-PLA NPs show much better tumor inhibition efficacy and fewer side effects than the commercialized Taxol (R) formulation, strongly supporting their use as high-performance carriers for anti-cancer therapy. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | MEMBRANE EMULSIFICATION ; CANCER ; MICROSPHERES ; MACROPHAGES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320272000001 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/13406]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shandong Polytech Univ, Dept Food & Bioengn, Jinan 250353, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Zhanguo,You, Zuoxiang,Yang, Qinzheng,et al. Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(26):3239-3247. |
| APA | Yue, Zhanguo.,You, Zuoxiang.,Yang, Qinzheng.,Lv, Piping.,Yue, Hua.,...&Ma, Guanghui.(2013).Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs.JOURNAL OF MATERIALS CHEMISTRY B,1(26),3239-3247. |
| MLA | Yue, Zhanguo,et al."Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs".JOURNAL OF MATERIALS CHEMISTRY B 1.26(2013):3239-3247. |
入库方式： OAI收割
来源：过程工程研究所
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