Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier
文献类型：期刊论文
| 作者 | Liu, Xiangyou1,6; Wei, Wei2; Huang, Shijiao3,4; Lin, Shrong-Shi1; Zhang, Xin5; Zhang, Chuanmao3,4; Du, Yuguang6; Ma, Guanghui2; Li, Mei7; Mann, Stephen7 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:25页码:3136-3143 |
| 英文摘要 | Chemotherapy has been widely used in clinical practice for cancer treatment. A major challenge for a successful chemotherapy is to potentiate the anticancer activity, whilst reducing the severe side effects. In this context, we design a bio-inspired protein-gold nanoconstruct (denoted as AFt-Au hereafter) with a core-void-shell structure which exhibits a high selectivity towards carcinoma cells. Anticancer drug 5-fluorouracil (5-FU) can be sequestered into the void space of the construct to produce an integrated nanoscale hybrid AFt-AuFU that exhibits an increased cellular uptake of 5-FU. More importantly, AFt-Au, serving as a bio-nano-chemosensitizer, renders carcinoma cells more susceptible to 5-FU by cell-cycle regulation, and thus, leads to a dramatic decrease of the IC50 value (i.e. the drug concentration required to kill 50% of the cell population) of 5-FU in HepG2 cells from 138.3 mu M to 9.2 mu M. Besides HepG2 cells, a remarkably enhanced anticancer efficacy and potentially reduced side effects are also achieved in other cell lines. Our further work reveals that the drug 5-FU is internalized into cells with AFt-Au primarily via receptor-mediated endocytosis (RME). After internalization, AFt-AuFU colocalizes with lysosomes which trigger the release of 5-FU under acidic conditions. Overall, our approach provides a novel procedure in nanoscience that promises an optimal chemotherapeutic outcome. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | HORSE SPLEEN APOFERRITIN ; CANCER-CELLS ; FERRITIN RECEPTORS ; ANTICANCER DRUGS ; PHASE-TRANSITION ; CELLULAR UPTAKE ; IRON RELEASE ; CYCLIN-E ; NANOPARTICLES ; 5-FLUOROURACIL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319965800002 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/13602]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Peking Univ, MOE Key Lab Cell Proliferat & Differentiat, Coll Life Sci, Beijing 100871, Peoples R China 4.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Coll Life Sci, Beijing 100871, Peoples R China 5.Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA 6.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 7.Univ Bristol, Sch Chem, Ctr Organized Matter Chem, Bristol BS6 1TS, Avon, England |
| 推荐引用方式 GB/T 7714 | Liu, Xiangyou,Wei, Wei,Huang, Shijiao,et al. Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(25):3136-3143. |
| APA | Liu, Xiangyou.,Wei, Wei.,Huang, Shijiao.,Lin, Shrong-Shi.,Zhang, Xin.,...&Ma, Ding.(2013).Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier.JOURNAL OF MATERIALS CHEMISTRY B,1(25),3136-3143. |
| MLA | Liu, Xiangyou,et al."Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier".JOURNAL OF MATERIALS CHEMISTRY B 1.25(2013):3136-3143. |
入库方式： OAI收割
来源：过程工程研究所
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