Tailor-Made Charge-Conversional Nanocomposite for pH-Responsive Drug Delivery and Cell Imaging
文献类型：期刊论文
| 作者 | Chen, Yan ; Ai, Kelong ; Liu, Yanlan ; Lu,Lehui |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:1页码:655-663 |
| 关键词 | NEAR-INFRARED LIGHT UPCONVERTING NANOPARTICLES REVERSAL NANOPARTICLES MESOPOROUS SILICA DOXORUBICIN THERAPY LUMINESCENCE MICROSPHERES RELEASE POLYMER |
| 通讯作者 | lu,lh |
| 英文摘要 | imaging labels, therapeutic drugs, as well as many other agents can all be integrated into one nanoplatform to allow for molecular imaging and therapy. with this in mind, herein we report the first example of a tailor-made charge-conversional nanocomposite composed of mesoporous gamma-alo(oh) and upconversion nanoparticles (ucnps) via a simple and versatile method, and the obtained nanocomposite could be performed as a drug delivery carrier and applied for cell imaging. the nanocomposite (ucnps-al) was found to be able to efficiently transport dox, a typical chemotherapeutic anticancer drug, into the cancer cell and release dox from ucnps-al triggering by the mildly acidic environment. in vitro cell cytotoxicity assay verified that dox-loaded nanocomposites (ugnps-al-dox) exhibited greater cytotoxicity with respect to free dox at the same concentrations, because of the increase in cell uptake of anti-cancer drug delivery vehicles mediated by the charge-conversional property. moreover, the ucl emission from ucnps and the red fluorescence of dox allow the nanocomposite to track and monitor the drug delivery system simultaneously. these findings have opened up new insights into designing and producing the highly versatile multifunctional nanoparticles for simultaneous imaging and therapeutic applications. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329586300088 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/52350]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen, Yan,Ai, Kelong,Liu, Yanlan,et al. Tailor-Made Charge-Conversional Nanocomposite for pH-Responsive Drug Delivery and Cell Imaging[J]. acs applied materials & interfaces,2014,6(1):655-663. |
| APA | Chen, Yan,Ai, Kelong,Liu, Yanlan,&Lu,Lehui.(2014).Tailor-Made Charge-Conversional Nanocomposite for pH-Responsive Drug Delivery and Cell Imaging.acs applied materials & interfaces,6(1),655-663. |
| MLA | Chen, Yan,et al."Tailor-Made Charge-Conversional Nanocomposite for pH-Responsive Drug Delivery and Cell Imaging".acs applied materials & interfaces 6.1(2014):655-663. |
入库方式： OAI收割
来源：长春应用化学研究所
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