Graphene Platform Used for Electrochemically Discriminating DNA Triplex
文献类型：期刊论文
| 作者 | Feng, Lingyan ; Zhang, Zhijun ; Ren, Jinsong ; Qu,Xiaogang |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:5页码:3513-3519 |
| 关键词 | RANGE GUANINE DAMAGE SINGLE-STRANDED-DNA CARBON NANOTUBES CHARGE-TRANSPORT ELECTROCATALYTIC OXIDATION ELECTRON-TRANSFER DUPLEX OXIDE ACID BIOSENSORS |
| 通讯作者 | qu,xg |
| 英文摘要 | triplex dna has received great attention as new molecular biology tools and therapeutic agents due to their possible novel functions in biology systems. therefore, it is important to distinguish triplex from among different forms of dna, such as single-stranded and double-stranded dna. in this report, several electrochemical techniques, cyclic voltammetry, electrochemical impedance spectroscopy, different pulse voltammetry, and electrochemiluminescence were used for distinguishing this unique structure among different dna formations by using functionalized graphene/nafion- ru(bpy)(3)(2+) (bpy = 2, 2'-bipyridine) modified glass carbon electrode. the different interactions between nucleotides and graphene surface and ru(bpy)(3)(2+) mediated guanine oxidation produced quite different electrochemical responses. guanine bases are hidden inside the folded triplex dnas, which are much less susceptible to be oxidized by ru(bpy)(3)(3+) produced on electrodes. furthermore, the effect of guanine bases stacking in triplex also influences the electrochemical behaviors. by changing the different position and distance of guanine bases in dna sequences, we found that the conjoint way of several guanines strongly influenced the catalytic electrochemical responses on graphene surface. our results provide new insight into determination of less stable protonated triplex formation by using graphene-based rapid, low-cost and sensitive electrochemical techniques. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000332922900060 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/52359]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng, Lingyan,Zhang, Zhijun,Ren, Jinsong,et al. Graphene Platform Used for Electrochemically Discriminating DNA Triplex[J]. acs applied materials & interfaces,2014,6(5):3513-3519. |
| APA | Feng, Lingyan,Zhang, Zhijun,Ren, Jinsong,&Qu,Xiaogang.(2014).Graphene Platform Used for Electrochemically Discriminating DNA Triplex.acs applied materials & interfaces,6(5),3513-3519. |
| MLA | Feng, Lingyan,et al."Graphene Platform Used for Electrochemically Discriminating DNA Triplex".acs applied materials & interfaces 6.5(2014):3513-3519. |
入库方式： OAI收割
来源：长春应用化学研究所
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