Near-Infrared Light-Triggered Drug-Delivery Vehicle for Mitochondria-Targeted Chemo-Photothermal Therapy
文献类型：期刊论文
| 作者 | Ju, Enguo ; Li, Zhenhua ; Liu, Zhen ; Ren,Jinsong ; Qu,Xiaogang |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:6页码:4364-4370 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES WALLED CARBON NANOTUBES CANCER-CELLS IN-VIVO INTRACELLULAR DELIVERY SURFACE-CHEMISTRY GOLD NANORODS LIPOSOMES DNA TRIPHENYLPHOSPHONIUM |
| 通讯作者 | ren,js |
| 英文摘要 | a novel drug-delivery vehicle for mitochondria-targeted chemo-photothermal therapy was demonstrated. a cytochrome c-specific binding aptamer was employed to make the mesoporous silica-encapsulated gold nanorods efficiently accumulate in the mitochondria of cancer cells. this nanocarrier can load various hydrophobic therapeutic agents acting on mitochondria to enhance the therapeutic efficiency and simultaneously depress the toxic side effects. in addition, near-ir treatment could induce cytochrome c release and initiation of the mitochondrial pathway of apoptosis. importantly, this multifunctional platform could integrate targeting, light-triggered release, and chemo-photothermal therapy into one system. we hope that such a system could open the door to the fabrication of a multifunctional mitochondria-targeted drug-delivery vehicle for cancer therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000333551500075 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/52360]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ju, Enguo,Li, Zhenhua,Liu, Zhen,et al. Near-Infrared Light-Triggered Drug-Delivery Vehicle for Mitochondria-Targeted Chemo-Photothermal Therapy[J]. acs applied materials & interfaces,2014,6(6):4364-4370. |
| APA | Ju, Enguo,Li, Zhenhua,Liu, Zhen,Ren,Jinsong,&Qu,Xiaogang.(2014).Near-Infrared Light-Triggered Drug-Delivery Vehicle for Mitochondria-Targeted Chemo-Photothermal Therapy.acs applied materials & interfaces,6(6),4364-4370. |
| MLA | Ju, Enguo,et al."Near-Infrared Light-Triggered Drug-Delivery Vehicle for Mitochondria-Targeted Chemo-Photothermal Therapy".acs applied materials & interfaces 6.6(2014):4364-4370. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。