Stimuli-Responsive Polypropylene for the Sustained Delivery of TPGS and Interaction with Erythrocytes
文献类型：期刊论文
| 作者 | Li, Chunming ; Jin, Jing ; Liu, Jingchuan ; Xu,Xiaodong ; Yin,Jinghua |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:16页码:13956-13967 |
| 关键词 | RED-BLOOD-CELLS VITAMIN-E TPGS LIPID-PEROXIDATION OXIDATIVE STRESS DRUG-DELIVERY PLATELET-ADHESION MEMBRANE PLASMA NANOPARTICLES HEMOLYSIS |
| 通讯作者 | jin,j |
| 英文摘要 | hemocompatibility and oxidative stress are significant for blood-contacting devices. in this study, n-isopropylacrylamide (nipaam) and n-(3-aminopropyl)methacrylamide hydrochloride (apma) were cografted on polypropylene (pp) membrane using ultraviolet grafting to load antioxidative d-alpha-tocopheryl polyethylene glycol 1000 succinate (tpgs) and control the release of tpgs. the immobilization of nipaam and apma onto pp membrane was confirmed by attenuated total reflectance fourier-transform infrared spectroscopy and x-ray photoelectron spectroscopy. combined with data from platelet adhesion, red blood cell (rbc) attachment, and hemolysis rate, the hemocompatibility of pp was significantly improved. an in-depth characterization using hemolysis rate test, scanning electron microscopy, atomic force microscopy, and confocal laser scanning microscopy was conducted to confirm that the mechanism of the release of tpgs interacted with rbcs was different at different stages. the release of tpgs from the loading pp membranes affected hemolysis at different stages. at the early stage of release, tpgs maintained the tiny (nanometer-sized) tubers on the membrane surface and enhanced the membrane permeabilization by generating nanosized pores on the cell membranes. afterward, the incorporated tpgs slowed the lipid peroxidation of erythrocytes and filled in the lipid bilayer of erythrocyte to prevent hemolysis. thus, the approach implemented to graft nipaam and apma and load tpgs was suitable to develop medical device with excellent hemocompatibility and antioxidative property. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341122000078 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/52371]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, Chunming,Jin, Jing,Liu, Jingchuan,et al. Stimuli-Responsive Polypropylene for the Sustained Delivery of TPGS and Interaction with Erythrocytes[J]. acs applied materials & interfaces,2014,6(16):13956-13967. |
| APA | Li, Chunming,Jin, Jing,Liu, Jingchuan,Xu,Xiaodong,&Yin,Jinghua.(2014).Stimuli-Responsive Polypropylene for the Sustained Delivery of TPGS and Interaction with Erythrocytes.acs applied materials & interfaces,6(16),13956-13967. |
| MLA | Li, Chunming,et al."Stimuli-Responsive Polypropylene for the Sustained Delivery of TPGS and Interaction with Erythrocytes".acs applied materials & interfaces 6.16(2014):13956-13967. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。