Preclinical Evaluation of Antitumor Activity of Acid-Sensitive PEGylated Doxorubicin
文献类型：期刊论文
| 作者 | Sun, Diankui ; Ding, Jianxun ; Xiao, Chunsheng ; Chen,Jinjin ; Zhuang,Xiuli ; Chen,Xuesi |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:23页码:21202-21214 |
| 关键词 | INTRACELLULAR DRUG-DELIVERY CANCER-THERAPY POLYPEPTIDE NANOGELS POLYMERIC MICELLES TARGETED DELIVERY RATIONAL DESIGN IN-VITRO PH NANOPARTICLES ANTICANCER |
| 通讯作者 | ding,jx |
| 英文摘要 | the acid-sensitive pegylated doxorubicin (dox) with exact chemical structure was designed and prepared as a potential tumor intracellular microenvironment-responsive drug delivery system. first, the insensitive succinic anhydride-functionalized dox (i.e., sad) and acid-sensitive cis-aconitic anhydride-modified dox (i.e., cad) were synthesized through the ring-opening reaction. subsequently, the insensitive and acid-sensitive pegylated dox (i.e., mpeg-sad and mpeg-cad) was prepared by the condensation reaction between the terminal hydroxyl group of mpeg and the carboxyl group in sad and cad, respectively. the obtained mpeg-sad and mpeg-cad could spontaneously self-assemble into micelles in phosphate-buffered saline at ph 7.4 with diameters of about 100 nm. the dox release of mpeg-cad micelle could be accelerated by the decrease of ph from 7.4, 6.8, to 5.5 in relation to that of mpeg-sad micelle. on the other hand, the result of the cellular proliferation inhibition test indicated that mpeg-cad micelle exhibited favorable antiproliferative activity in vitro. in addition, the selective intratumoral accumulation and antitumor efficacy of mpeg-cad micelle were significantly better than those of free dox and mpeg-sad. more importantly, the prodrug micelles exhibited upregulated security in vivo as compared to free dox. overall, the mpeg-cad micelle with enhanced antitumor efficacy and decreased side effects was a fascinating prospect for the clinical chemotherapy of malignancy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346326600076 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/52379]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun, Diankui,Ding, Jianxun,Xiao, Chunsheng,et al. Preclinical Evaluation of Antitumor Activity of Acid-Sensitive PEGylated Doxorubicin[J]. acs applied materials & interfaces,2014,6(23):21202-21214. |
| APA | Sun, Diankui,Ding, Jianxun,Xiao, Chunsheng,Chen,Jinjin,Zhuang,Xiuli,&Chen,Xuesi.(2014).Preclinical Evaluation of Antitumor Activity of Acid-Sensitive PEGylated Doxorubicin.acs applied materials & interfaces,6(23),21202-21214. |
| MLA | Sun, Diankui,et al."Preclinical Evaluation of Antitumor Activity of Acid-Sensitive PEGylated Doxorubicin".acs applied materials & interfaces 6.23(2014):21202-21214. |
入库方式： OAI收割
来源：长春应用化学研究所
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