Nanoscale Organization of Human GnRH-R on Human Bladder Cancer Cells
文献类型：期刊论文
| 作者 | Zhang, Jing ; Chtcheglova, Lilia A. ; Zhu, Rong ; Hinterdorfer,Peter ; Zhang,Bailin ; Tang,Jilin |
| 刊名 | analytical chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 86期号:5页码:2458-2464 |
| 关键词 | GONADOTROPIN-RELEASING-HORMONE ATOMIC-FORCE MICROSCOPY SIMULTANEOUS TOPOGRAPHY RECOGNITION EVENTS ENDOTHELIAL-CELLS LOCALIZATION RECEPTOR ANTAGONISTS DELIVERY TISSUES |
| 通讯作者 | zhang,bl |
| 英文摘要 | human gonadotropin-releasing hormone receptor (gnrh-r; or type i gnrh-r), which is expressed in tumor cells, has gained more and more attention as,a specific target for cancer therapy. given the clinical utility, the improved characterization of both the subcellular distribution and surface organization of gnrh-r is an important step in the development of more effective and possibly new therapeutic strategies. in the present study, the nano-organization of human gnrh-r was analyzed on fixed human bladder cancer cells (t24) by atomic force microscopy (afm). the recognition images reveal that gnrh-rs have a tendency to assemble in nanodomains (or clusters) that are irregularly distributed on the t24 cell surface. the locations of the gnrh-rs were identified on the topographical images with nanometer accuracy. the obtained results enrich our understanding of the local distribution of gnrh-rs on the bladder cancer cell membrane and demonstrate the ability of biological afm to provide more complete and exact information at the single molecule level. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000332494100028 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/52384]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang, Jing,Chtcheglova, Lilia A.,Zhu, Rong,et al. Nanoscale Organization of Human GnRH-R on Human Bladder Cancer Cells[J]. analytical chemistry,2014,86(5):2458-2464. |
| APA | Zhang, Jing,Chtcheglova, Lilia A.,Zhu, Rong,Hinterdorfer,Peter,Zhang,Bailin,&Tang,Jilin.(2014).Nanoscale Organization of Human GnRH-R on Human Bladder Cancer Cells.analytical chemistry,86(5),2458-2464. |
| MLA | Zhang, Jing,et al."Nanoscale Organization of Human GnRH-R on Human Bladder Cancer Cells".analytical chemistry 86.5(2014):2458-2464. |
入库方式： OAI收割
来源：长春应用化学研究所
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