Upconverting Nanoparticles with a Mesoporous TiO2 Shell for Near-Infrared-Triggered Drug Delivery and Synergistic Targeted Cancer Therapy
文献类型：期刊论文
| 作者 | Yin, Meili ; Ju, Enguo ; Chen, Zhaowei ; Li,Zhenhua ; Ren,Jinsong ; Qu,Xiaogang |
| 刊名 | chemistry-a european journal
 |
| 出版日期 | 2014 |
| 卷号 | 20期号:43页码:14012-14017 |
| 关键词 | UP-CONVERSION NANOPARTICLES IN-VIVO PHOTODYNAMIC THERAPY NANOPROBES HYALURONAN MECHANISMS RELEASE SYSTEM VITRO |
| 通讯作者 | ren,js |
| 英文摘要 | malignant tumors remain a major health burden throughout the world and effective therapeutic strategies are urgently needed. herein, we report the synthesis of upconverting nanoparticles with a mesoporous tio2 (mtio(2)) shell for near-infrared (nir)-triggered drug delivery and synergistic targeted cancer therapy. the nagdf4:yb, tm could convert nir light to uv light, which activated the mtio(2) to produce reactive oxygen species for photodynamic therapy (pdt). due to the large surface area and porous structure, the mtio(2) shell endowed the nanoplatform with another functionality of anticancer drug loading for chemotherapy. the hyaluronic acid modified on the surface not only promised controlled drug release but also conferred targeted ability of the system toward cluster determinant 44 overexpressed cancer cells. more importantly, cytotoxicity experiments demonstrated that combined therapy mediated the highest rate of death of breast carcinoma cells compared with that of single chemotherapy or pdt. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343800700028 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/52408]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yin, Meili,Ju, Enguo,Chen, Zhaowei,et al. Upconverting Nanoparticles with a Mesoporous TiO2 Shell for Near-Infrared-Triggered Drug Delivery and Synergistic Targeted Cancer Therapy[J]. chemistry-a european journal,2014,20(43):14012-14017. |
| APA | Yin, Meili,Ju, Enguo,Chen, Zhaowei,Li,Zhenhua,Ren,Jinsong,&Qu,Xiaogang.(2014).Upconverting Nanoparticles with a Mesoporous TiO2 Shell for Near-Infrared-Triggered Drug Delivery and Synergistic Targeted Cancer Therapy.chemistry-a european journal,20(43),14012-14017. |
| MLA | Yin, Meili,et al."Upconverting Nanoparticles with a Mesoporous TiO2 Shell for Near-Infrared-Triggered Drug Delivery and Synergistic Targeted Cancer Therapy".chemistry-a european journal 20.43(2014):14012-14017. |
入库方式： OAI收割
来源：长春应用化学研究所
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