Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus
文献类型：期刊论文
| 作者 | Li, Kecheng; Xing, Ronge ; Liu, Song; Qin, Yukun; Yu, Huahua; Li, Pengcheng
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 64页码:302-305 |
| 关键词 | Chitooligomers Size Antibacterial activity |
| 通讯作者 | Li, PC (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 英文摘要 | The antimicrobial activity of chitooligomers (COSs) has attracted considerable interest but there are few reports on antibacterial activity of each individual COS. This study focuses on investigating the size and pH effects of COS on its antibacterial activity against Staphylococcus aureus. Minimum inhibitory concentrations (MICs) of five single COSs and five COS fractions with narrow degrees of polymerization (DP) were determined at different pH mediums. The results revealed that the antibacterial activity of COS required structural essential with a DP of at least 5 and the inhibitory effect increased with increasing DP. Lower pH value could enhance the antibacterial activity of COS. The COS with DP > 12 showed a MIC value of 62.5 mg/mL at pH 6.0, while the MIC value increased to 500 and 1000 mg/mL at pH 6.5 and 7.0, respectively. The cell membrane integrity assay and SEM suggested that the COS with high DP could cause bacteria clustering and further lysis of cell. (C) 2013 Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334147300045 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/24242]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 海洋研究所_海洋环境工程技术研究发展中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Kecheng,Xing, Ronge,Liu, Song,et al. Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,64:302-305. |
| APA | Li, Kecheng,Xing, Ronge,Liu, Song,Qin, Yukun,Yu, Huahua,&Li, Pengcheng.(2014).Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,64,302-305. |
| MLA | Li, Kecheng,et al."Size and pH effects of chitooligomers on antibacterial activity against Staphylococcus aureus".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 64(2014):302-305. |
入库方式： OAI收割
来源：海洋研究所
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