Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis
文献类型：期刊论文
| 作者 | Davaatseren, Munkhtugs1,2; Hwang, Jin-Taek1; Park, Jae Ho1; Kim, Myung-Sunny1; Wang, Shuaiyu3; Sung, Mi Jeong1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014-07-22 |
| 卷号 | 9期号:7页码:e102975 |
| 通讯作者 | Sung, MJ (reprint author), Korea Food Res Inst, Res Div Emerging Innovat Technol, Songnam, Keongki, South Korea. |
| 英文摘要 | Allyl isothiocyanate (AITC) is a phytochemical found in cruciferous vegetables that has known chemopreventive and chemotherapeutic activities. Thus far, the antiangiogenic activity of AITC has not been reported in in vivo studies. Herein, we investigated the effect of AITC on angiogenesis and inflammation in a mouse model of colitis. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium via drinking water. To monitor the activity of AITC in this model, we measured body weight, disease activity indices, histopathological scores, microvascular density, myeloperoxidase activity, F4/80 staining, inducible nitric oxide synthase (iNOS) expression, cyclooxygenase-2 (COX-2) expression, and vascular endothelial growth factor (VEGF)-A/VEGF receptor 2 (VEGFR2) expression in the mice. We found that AITC-treated mice showed less weight loss, fewer clinical signs of colitis, and longer colons than vehicle-treated mice. AITC treatment also significantly lessened the disruption of colonic architecture that is normally associated with colitis and repressed the microvascularization response. Further, AITC treatment reduced both leukocyte recruitment and macrophage infiltration into the inflamed colon, and the mechanism these activities involved repressing iNOS and COX-2 expression. Finally, AITC attenuated the expression of VEGF-A and VEGFR2. Thus, AITC may have potential application in treating conditions marked by inflammatory-driven angiogenesis and mucosal inflammation. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339551100073 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/24068]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Korea Food Res Inst, Res Div Emerging Innovat Technol, Songnam, Keongki, South Korea 2.Konkuk Univ, Dept Bioresources & Food Sci, Seoul, South Korea 3.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Davaatseren, Munkhtugs,Hwang, Jin-Taek,Park, Jae Ho,et al. Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis[J]. PLOS ONE,2014,9(7):e102975. |
| APA | Davaatseren, Munkhtugs,Hwang, Jin-Taek,Park, Jae Ho,Kim, Myung-Sunny,Wang, Shuaiyu,&Sung, Mi Jeong.(2014).Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis.PLOS ONE,9(7),e102975. |
| MLA | Davaatseren, Munkhtugs,et al."Allyl Isothiocyanate Ameliorates Angiogenesis and Inflammation in Dextran Sulfate Sodium-Induced Acute Colitis".PLOS ONE 9.7(2014):e102975. |
入库方式： OAI收割
来源：海洋研究所
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