Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction
文献类型：期刊论文
| 作者 | Sun, Zheng1; Li, Shihao1,2; Li, Fuhua1,2; Xiang, Jianhai1
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| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2014 |
| 页码 | 416543 |
| 通讯作者 | Li, FH (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China. |
| 英文摘要 | WSSV is one of the most dangerous pathogens in shrimp aquaculture. However, the molecular mechanism of how WSSV interacts with shrimp is still not very clear. In the present study, bioinformatic approaches were used to predict interactions between proteins from WSSV and shrimp. The genome data of WSSV (NC_003225.1) and the constructed transcriptome data of F. chinensis were used to screen potentially interacting proteins by searching in protein interaction databases, including STRING, Reactome, and DIP. Forty-four pairs of proteins were suggested to have interactions between WSSV and the shrimp. Gene ontology analysis revealed that 6 pairs of these interacting proteins were classified into "extracellular region" or "receptor complex" GO-terms. KEGG pathway analysis showed that they were involved in the "ECM-receptor interaction pathway." In the 6 pairs of interacting proteins, an envelope protein called "collagen-like protein" (WSSV-CLP) encoded by an early virus gene "wsv001" in WSSV interacted with 6 deduced proteins from the shrimp, including three integrin alpha (ITGA), two integrin beta (ITGB), and one syndecan (SDC). Sequence analysis on WSSV-CLP, ITGA, ITGB, and SDC revealed that they possessed the sequence features for protein-protein interactions. This study might provide new insights into the interaction mechanisms between WSSV and shrimp. |
| 学科主题 | Biotechnology & Applied Microbiology; Research & Experimental Medicine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336597100001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/24077]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Zheng,Li, Shihao,Li, Fuhua,et al. Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction[J]. BIOMED RESEARCH INTERNATIONAL,2014:416543. |
| APA | Sun, Zheng,Li, Shihao,Li, Fuhua,&Xiang, Jianhai.(2014).Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction.BIOMED RESEARCH INTERNATIONAL,416543. |
| MLA | Sun, Zheng,et al."Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction".BIOMED RESEARCH INTERNATIONAL (2014):416543. |
入库方式： OAI收割
来源：海洋研究所
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