Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway
文献类型：期刊论文
| 作者 | Liu, Jia1,3; Zheng, Lanhong2; Wu, Ning1; Ma, Leina4; Zhong, Jiateng5; Liu, Ge1,3; Lin, Xiukun1,6 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2014-06-18 |
| 卷号 | 62期号:24页码:5528-5537 |
| 关键词 | aerobic glycolysis AMPK metabolism oleanolic acid |
| 通讯作者 | Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 英文摘要 | Cancer cells are well-known to require a constant supply of protein, lipid, RNA, and DNA via altered metabolism for accelerated cell proliferation. Targeting metabolic pathways is, therefore, a promising therapeutic strategy for cancers. Oleanolic acid (OA) is widely distributed in dietary and medicinal plants and displays a selective cytotoxicity to cancer cells, primarily by inducing apoptosis and cell cycle arrest. This study investigated if OA inhibited growth of tumor cells by affecting their metabolism. OA was found to activate AMP-activated protein kinase (AMPK), the master regulator of metabolism, in prostate cancer cell line PC-3 and breast cancer cell line MCF-7. AMPK activation is required for the antitumor activity of OA on cancer cells. Lipogenesis, protein synthesis, and aerobic glycolysis were inhibited in cancer cells treated with OA, in an AMPK activation-dependent manner. The metabolic alteration was shown to mediate the tumor suppressor activity of OA on cancer cells. Collectively, this study provides evidence that OA, as a widely distributed nutritional component, is able to exert antitumor function by interfering in the metabolic pathway in cancer cells. This finding should encourage researchers to study if affecting cancer metabolism is a common mechanism by which nutritional compounds suppress cancers. |
| 学科主题 | Agriculture; Chemistry; Food Science & Technology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337720100016 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/24137]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China 5.Jilin Univ, Dept Pathophysiol, Norman Bethune Coll Med, Changchun 130021, Peoples R China 6.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jia,Zheng, Lanhong,Wu, Ning,et al. Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2014,62(24):5528-5537. |
| APA | Liu, Jia.,Zheng, Lanhong.,Wu, Ning.,Ma, Leina.,Zhong, Jiateng.,...&Lin, Xiukun.(2014).Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,62(24),5528-5537. |
| MLA | Liu, Jia,et al."Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62.24(2014):5528-5537. |
入库方式： OAI收割
来源：海洋研究所
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