Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy
文献类型：期刊论文
| 作者 | Liu, Jia1,3; Zheng, Lanhong2; Ma, Leina4; Wang, Bin5 ; Zhao, Youguang6; Wu, Ning3; Liu, Ge3; Lin, Xiukun3,7
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| 刊名 | JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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| 出版日期 | 2014-11-01 |
| 卷号 | 25期号:11页码:1154-1160 |
| 关键词 | Oleanolic acid Autophagy Akt Cancer prevention Natural compounds |
| 通讯作者 | Lin, XK (reprint author), Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China. |
| 英文摘要 | Oleanolic acid (OA) has been widely studied because of its pleiotropic therapeutic and preventive effect on various diseases. However, the mechanisms of OA's action are still not clear yet, especially its suppressing effect on transformed cells. In this work, we found that OA induced autophagy in normal tissue-derived cells without cytotoxicity. OA-induced autophagy was shown to decrease the proliferation of KRAS-transformed normal cells and to impair their invasion and anchorage-independent growth. Interrupting autophagy rescued OA's effect on the transformed cells. Mouse model experiments also demonstrated that OA suppressed the growth of KRAS-transformed breast epithelial cell MCF10A-derived tumor xenograft by inducing autophagy. Finally, we identified that OA induced autophagy in normal cells by inhibiting the activation of Akt/mTOR/S6K signaling. In conclusions, we found that OA treatment permitted normal cells to undergo autophagy. The induced autophagy was required for OA to prevent or delay the growth of transformed normal cells. (C) 2014 Published by Elsevier Inc. |
| 学科主题 | Biochemistry & Molecular Biology; Nutrition & Dietetics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344205600007 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/24139]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Qingdao Univ, Coll Med, Qingdao 266021, Peoples R China 2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Dept Mol Biol, Qingdao 266003, Peoples R China 5.Third Militaty Med Univ, Daping Hosp, Inst Surg Res, Dept Gastroenterol, Chongqing 400042, Peoples R China 6.Chinese PLA, Chengdu Mil Area Command, Gen Hosp, Dept Urol, Chengdu 610083, Peoples R China 7.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jia,Zheng, Lanhong,Ma, Leina,et al. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2014,25(11):1154-1160. |
| APA | Liu, Jia.,Zheng, Lanhong.,Ma, Leina.,Wang, Bin.,Zhao, Youguang.,...&Lin, Xiukun.(2014).Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,25(11),1154-1160. |
| MLA | Liu, Jia,et al."Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25.11(2014):1154-1160. |
入库方式： OAI收割
来源：海洋研究所
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