Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle
文献类型：期刊论文
| 作者 | Liu, YH ; Chen, YB ; Mao, W ; Hu, L ; Deng, LH ; Xu, HQ |
| 刊名 | FRONTIERS OF PHYSICS
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:4页码:519-522 |
| 关键词 | MEDIATED ENDOCYTOSIS CELLULAR UPTAKE CELLS MECHANISM SIZE |
| ISSN号 | 2095-0462 |
| 通讯作者 | Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China. |
| 英文摘要 | Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and the optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of receptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [11047022, 11204045, 31360215]; Research Foundation from Ministry of Education of China [2012152]; Guizhou Provincial Tracking Key Program of Social Development [SY20123089, SZ20113069]; Natural Science Foundation of Guizhou Province [J20122166]; Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education (Chongqing University) |
| 原文出处 | http://dx.doi.org/10.1007/s11467-014-0412-6 |
| 语种 | 英语 |
| WOS记录号 | WOS:000341429900012 |
| 公开日期 | 2015-06-03 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/15691]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 推荐引用方式 GB/T 7714 | Liu, YH,Chen, YB,Mao, W,et al. Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle[J]. FRONTIERS OF PHYSICS,2014,9(4):519-522. |
| APA | Liu, YH,Chen, YB,Mao, W,Hu, L,Deng, LH,&Xu, HQ.(2014).Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle.FRONTIERS OF PHYSICS,9(4),519-522. |
| MLA | Liu, YH,et al."Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle".FRONTIERS OF PHYSICS 9.4(2014):519-522. |
入库方式： OAI收割
来源：理论物理研究所
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