Morphological changes in capillaries in the ischemic brain in Wistar rats
文献类型：期刊论文
| 作者 | Taguchi, Y. |
| 刊名 | Archives of Histology and Cytology
 |
| 出版日期 | 2004 |
| 卷号 | 67期号:3页码:253-261 |
| ISSN号 | 0914-9465 |
| 中文摘要 | The microvasculature in the brain plays a vital role in the maintenance of brain perfusion, and fulfills the dynamic requirements of normal brain functions. It is well known that collateral circulation can be induced by ischemia in cerebral infarctions, but it is not known whether cerebral ischemia affects microvasculatures in the ischemic region. In the present study, we examined quantitatively serial changes in capillaries following bilateral common carotid artery ligation in Wistar rats. After the animals were perfused with tetramethylrhodamine isothiocyanate-labeled gelatin 3 h (n = 9), 1 day (n = 9), 7 days (n = 9) and 28 days (n = 9) after the ligation, capillary diameters in the brain sections were measured with a confocal laser-scanning microscope. Capillary diameters of the cerebellum did not differ among all groups, while those in the ischemic regions decreased significantly 3h after the ligation (p<0.01), thereafter gradually returned toward the baseline level, and became significantly larger (168% of the control) 28 days after the ligation (p<0.01). The density of capillaries in the frontal and parietal cortices increased approximately to 1.3-fold of those of the control level 28 days after the ligation. Transmission electron microscopy showed that the mean ratio of the inner diameter to the outer diameter of capillaries in the frontal cortex became significantly greater 28 days after the ligation (p<0.05). Our data indicate that capillaries dilate in the ischemic brain region in the chronic phase of cerebral ischemia. It is also suggested that neovascularization occurs in the ischemic brain region. |
| 语种 | 英语 |
| 公开日期 | 2015-06-08 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/8881]  |
| 专题 | 西双版纳热带植物园_公共技术服务中心主要仪器相关文献_激光共聚焦显微镜 |
| 推荐引用方式 GB/T 7714 | Taguchi, Y.. Morphological changes in capillaries in the ischemic brain in Wistar rats[J]. Archives of Histology and Cytology,2004,67(3):253-261. |
| APA | Taguchi, Y..(2004).Morphological changes in capillaries in the ischemic brain in Wistar rats.Archives of Histology and Cytology,67(3),253-261. |
| MLA | Taguchi, Y.."Morphological changes in capillaries in the ischemic brain in Wistar rats".Archives of Histology and Cytology 67.3(2004):253-261. |
入库方式： OAI收割
来源：西双版纳热带植物园
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