Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents
文献类型：期刊论文
| 作者 | Wang, Li-Jun; Wang, Shuai-Yu; Jiang, Bo; Wu, Ning; Li, Xiang-Qian; Wang, Bao-Cheng; Luo, Jiao; Yang, Meng; Jin, Shui-Hua; Shi, Da-Yong |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2015-02-01 |
| 卷号 | 13期号:2页码:806-823 |
| 英文摘要 | A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds (4g-4i, 5h, 6d, 7a, 7b) showed potent activity against the tested five human cancer cell lines. Wound-healing assay demonstrated that compound 4g can be used as a potent compound for inactivating invasion and metastasis by inhibiting the migration of cancer cells. The structure-activity relationships (SARs) of bromophenol derivatives had been discussed, which were useful for exploring and developing bromophenol derivatives as novel anticancer drugs. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350217500008 |
| 公开日期 | 2015-06-16 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/25392]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Li-Jun,Wang, Shuai-Yu,Jiang, Bo,et al. Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents[J]. MARINE DRUGS,2015,13(2):806-823. |
| APA | Wang, Li-Jun.,Wang, Shuai-Yu.,Jiang, Bo.,Wu, Ning.,Li, Xiang-Qian.,...&Shi, Da-Yong.(2015).Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents.MARINE DRUGS,13(2),806-823. |
| MLA | Wang, Li-Jun,et al."Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents".MARINE DRUGS 13.2(2015):806-823. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。