Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas
文献类型：期刊论文
| 作者 | Huang, Baoyu1,2 ; Zhang, Linlin1; Li, Li1; Tang, Xueying1,2; Zhang, Guofan1
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| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 43期号:2页码:485-490 |
| 关键词 | Crassostrea gigas FREP Innate immune Genome expansion Sequence diversity |
| 英文摘要 | Fibrinogen-related proteins (FREPs) are a family of proteins with high sequence diversity, and they play crucial roles in invertebrate immune response. However, few studies have characterized this diversity at the whole-genome level. In the present study, approximately 190 predicted FREPs with more than 200 fibrinogen-like (FBG) domains were identified in the genome of the Pacific oyster (Crassostrea gigas), suggesting a historical expansion of this protein family. A sequence analysis showed high numbers of polymorphisms in C. gigas FREP (CgFREP) genes, which may contribute to the versatile immune function of FREPs. A phylogenetic analysis of molluscan FREP sequences indicated lineage-specific duplication of these genes in C. gigas. Additionally, several CgFREP mRNAs were highly expressed in the gills, digestive glands, and hemocytes. Taken together, these findings will help elucidate FREP immune function and facilitate studies of the functional validation of this gene family. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352923700021 |
| 公开日期 | 2015-06-16 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/25478]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Baoyu,Zhang, Linlin,Li, Li,et al. Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2015,43(2):485-490. |
| APA | Huang, Baoyu,Zhang, Linlin,Li, Li,Tang, Xueying,&Zhang, Guofan.(2015).Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,43(2),485-490. |
| MLA | Huang, Baoyu,et al."Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 43.2(2015):485-490. |
入库方式： OAI收割
来源：海洋研究所
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