Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters
文献类型：期刊论文
| 作者 | Feng Q; Zhang L; Liu C; Li XY; Hu GQ(胡国庆) ; Sun JS; Jiang XY
|
| 刊名 | Biomicrofluidics
 |
| 出版日期 | 2015-09 |
| 卷号 | 9期号:5页码:52604 |
| 通讯作者邮箱 | sunjs@nanoctr.cn ; xingyujiang@nanoctr.cn |
| ISSN号 | 1932-1058 |
| 产权排序 | [Feng, Qiang; Zhang, Lu; Li, Xuanyu; Sun, Jiashu; Jiang, Xingyu] Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China; [Feng, Qiang; Zhang, Lu; Li, Xuanyu; Sun, Jiashu; Jiang, Xingyu] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liu, Chao; Hu, Guoqing] Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China |
| 通讯作者 | Feng, Q (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China. |
| 中文摘要 | Core-shell hybrid nanoparticles (NPs) for drug delivery have attracted numerous attentions due to their enhanced therapeutic efficacy and good biocompatibility. In this work, we fabricate a two-stage microfluidic chip to implement a high-throughput, one-step, and size-tunable synthesis of mono-disperse lipid-poly (lactic-co-glycolic acid) NPs. The size of hybrid NPs is tunable by varying the flow rates inside the two-stage microfluidic chip. To elucidate the mechanism of size-controllable generation of hybrid NPs, we observe the flow field in the microchannel with confocal microscope and perform the simulation by a numerical model. Both the experimental and numerical results indicate an enhanced mixing effect at high flow rate, thus resulting in the assembly of small and monodisperse hybrid NPs. In vitro experiments show that the large hybrid NPs are more likely to be aggregated in serum and exhibit a lower cellular uptake efficacy than the small ones. This microfluidic chip shows great promise as a robust platform for optimization of nano drug delivery system. (C) 2015 AIP Publishing LLC. |
| 分类号 | 一类 |
| 类目[WOS] | Biochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics |
| 关键词[WOS] | CORE-SHELL NANOPARTICLES ; CELLULAR UPTAKE ; PLGA NANOPARTICLES ; DRUG-DELIVERY ; PARTICLE-SIZE ; LIPOSOMES ; RELEASE ; DEVICES ; CAPSULES ; PLATFORM |
| 收录类别 | SCI ; EI |
| 原文出处 | http://dx.doi.org/10.1063/1.4922957 |
| 语种 | 英语 |
| WOS记录号 | WOS:000364407300005 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/52051]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Feng Q,Zhang L,Liu C,et al. Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters[J]. Biomicrofluidics,2015,9(5):52604. |
| APA | Feng Q.,Zhang L.,Liu C.,Li XY.,胡国庆.,...&Jiang XY.(2015).Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters.Biomicrofluidics,9(5),52604. |
| MLA | Feng Q,et al."Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters".Biomicrofluidics 9.5(2015):52604. |
入库方式： OAI收割
来源：力学研究所
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