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Hyperphosphorylation Results in Tau Dysfunction in DNA Folding and Protection

文献类型：期刊论文

作者Lu, Yang1,2; He, Hai-Jin1; Zhou, Jun1,4; Miao, Jun-Ye1,4; Lu, Jing1; He, Ying-Ge1; Pan, Rong1; Wei, Yan1; Liu, Ying1; He, Rong-Qiao1,3
刊名JOURNAL OF ALZHEIMERS DISEASE
出版日期2013
卷号37期号:3页码:551-563
关键词Alzheimer's disease DNA protection formaldehyde GSK-3 beta phosphorylation tau hyperphosphorylation tau protein tauopathy
ISSN号1387-2877
产权排序1,3
通讯作者He, RQ (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, 15 Datun Rd, Beijing 100101, Peoples R China.
英文摘要Hyperphosphorylation of tau occurs in preclinical and clinical stages of Alzheimer's disease (AD), and hyperphosphorylated tau is the main constituent of the paired helical filaments in the brains of mild cognitive impairment and AD patients. While most of the work described so far focused on the relationship between hyperphosphorylation of tau and microtubule disassembly as well as axonal transport impairments, both phenomena ultimately leading to cell death, little work has been done to study the correlation between tau hyperphosphorylation and DNA damage. As we showed in this study, tau hyperphosphorylation and DNA damage co-occurred under formaldehyde treatment in N2a cells, indicating that phosphorylated tau (p-Tau) induced by formaldehyde may be involved in DNA impairment. After phosphorylation, the effect of tau in preventing DNA from thermal denaturation was diminished, its ability to accelerate DNA renaturation was lost, and its function in protecting DNA from reactive oxygen species (ROS) attack was impaired. Thus, p-Tau is not only associated with the disassembly of the microtubule system, but also plays a crucial role in DNA impairment. Hyperphosphorylation-mediated dysfunction of tau protein in prevention of DNA structure from damage under the attack of ROS may provide novel insights into the mechanisms underlying tauopathies.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
学科主题Physiological psychology/Biological Psychology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GLYCOGEN-SYNTHASE KINASE-3-BETA ; ALZHEIMERS-DISEASE ; PROTEIN-TAU ; IN-VITRO ; POSTTRANSLATIONAL MODIFICATIONS ; CEREBROSPINAL-FLUID ; TRANSGENIC ANIMALS ; CROSS-LINKING ; NEURONAL TAU ; PHOSPHORYLATION
收录类别SCI
项目简介We thank Dr. Chan-Shuai Han for helpful comments in the experimental design and the entire He group for critical discussion of the manuscript. We also appreciate Dr. Goedert and Dr. Torsten Juelich for kindly providing the Prk172 vector and language editing, respectively. This project was supported by the 973-Project (2012CB911000; 2010CB912303), the Queensland-Chinese Academy of Sciences Biotechnology Fund (GJHZ1131) and the External Cooperation Program of BIC, Chinese Academy of Sciences (GJHZ201302).
原文出处http://library.ibp.ac.cn/html/slwj/000324918300010.pdf
语种英语
WOS记录号WOS:000324918300010
源URL[http://ir.psych.ac.cn/handle/311026/10791]  
专题心理研究所_脑与认知科学国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing 100101, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Yang,He, Hai-Jin,Zhou, Jun,et al. Hyperphosphorylation Results in Tau Dysfunction in DNA Folding and Protection[J]. JOURNAL OF ALZHEIMERS DISEASE,2013,37(3):551-563.
APA Lu, Yang.,He, Hai-Jin.,Zhou, Jun.,Miao, Jun-Ye.,Lu, Jing.,...&He, Rong-Qiao.(2013).Hyperphosphorylation Results in Tau Dysfunction in DNA Folding and Protection.JOURNAL OF ALZHEIMERS DISEASE,37(3),551-563.
MLA Lu, Yang,et al."Hyperphosphorylation Results in Tau Dysfunction in DNA Folding and Protection".JOURNAL OF ALZHEIMERS DISEASE 37.3(2013):551-563.

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来源：心理研究所

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