Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?
文献类型：期刊论文
| 作者 | Lui, Simon S. Y.1,2,3; Wang, Ya1 ; Yang, Tian-xiao1; Liu, Amy C. Y.3; Chui, William W. H.3; Yeung, Hera K. H.3; Li, Zhi1,2; Neumann, David L.4; Shum, David H. K.4; Cheung, Eric F. C.3
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| 刊名 | JOURNAL OF PSYCHIATRIC RESEARCH
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| 出版日期 | 2015-02-01 |
| 卷号 | 61期号:1页码:141-149 |
| 通讯作者邮箱 | rckchan@psych.ac.cn |
| 关键词 | Prospective memory Schizophrenia First-episode |
| ISSN号 | 0022-3956 |
| 通讯作者 | 陈楚侨 |
| 合作状况 | 国际 |
| 中文摘要 | Prospective memory (PM) is the ability to remember to carry out intended actions in the future. Empirical evidence suggests that PM deficits exist in individuals with chronic schizophrenia. However, it is unclear whether PM deficits in first-episode schizophrenia exist independently from other neuropsychological deficits. Moreover, prior research using patients with first-episode has been limited to small inpatient samples. We aimed to clarify the nature and extent of PM deficits in individuals with first-episode schizophrenia, using a large outpatient sample. Participants were 91 clinically stable outpatients with first-episode schizophrenia and 83 healthy controls. PM was assessed using both a subjective self-reported checklist and a laboratory-based task capturing time- and event-based PM. A battery assessing verbal and visuo-spatial working memory, as well as executive functions was also administered. ANOVA analyses showed that patients with first-episode schizophrenia performed significantly poorer than healthy controls in time- and event-based PM. Stepwise linear regression analyses suggested that cognitive flexibility predicted time- and event-based PM; and working memory predicted event-based PM. Subgroup analyses showed that “cognitive-preserved” patients with first-episode schizophrenia tended to perform poorer in time-based PM deficit than healthy controls who were matched in IQ and other neuropsychological functions. Overall, our results provide substantial evidence to support that time-based PM deficits in first-episode schizophrenia are apparent and not entirely attributable to other neuropsychological deficits. PM may constitute a neuropsychological marker for schizophrenia. |
| 英文摘要 | Prospective memory (PM) is the ability to remember to carry out intended actions in the future. Empirical evidence suggests that PM deficits exist in individuals with chronic schizophrenia. However, it is unclear whether PM deficits in first-episode schizophrenia exist independently from other neuropsychological deficits. Moreover, prior research using patients with first-episode has been limited to small inpatient samples. We aimed to clarify the nature and extent of PM deficits in individuals with first-episode schizophrenia, using a large outpatient sample. Participants were 91 clinically stable outpatients with first-episode schizophrenia and 83 healthy controls. PM was assessed using both a subjective self-reported checklist and a laboratory-based task capturing time- and event-based PM. A battery assessing verbal and visuo-spatial working memory, as well as executive functions was also administered. ANOVA analyses showed that patients with first-episode schizophrenia performed significantly poorer than healthy controls in time- and event-based PM. Stepwise linear regression analyses suggested that cognitive flexibility predicted time- and event-based PM; and working memory predicted event-based PM. Subgroup analyses showed that "cognitive-preserved" patients with first-episode schizophrenia tended to perform poorer in time-based PM deficit than healthy controls who were matched in IQ and other neuropsychological functions. Overall, our results provide substantial evidence to support that time-based PM deficits in first-episode schizophrenia are apparent and not entirely attributable to other neuropsychological deficits. PM may constitute a neuropsychological marker for schizophrenia. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | 医学心理学 |
| 收录类别 | SCI ; SSCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0022395614003161# |
| 语种 | 英语 |
| WOS记录号 | WOS:000349731000019 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10189]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Chen CQ(陈楚侨) |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 4.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Res Program, Gold Coast, Australia |
| 推荐引用方式 GB/T 7714 | Lui, Simon S. Y.,Wang, Ya,Yang, Tian-xiao,et al. Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2015,61(1):141-149. |
| APA | Lui, Simon S. Y..,Wang, Ya.,Yang, Tian-xiao.,Liu, Amy C. Y..,Chui, William W. H..,...&陈楚侨.(2015).Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?.JOURNAL OF PSYCHIATRIC RESEARCH,61(1),141-149. |
| MLA | Lui, Simon S. Y.,et al."Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?".JOURNAL OF PSYCHIATRIC RESEARCH 61.1(2015):141-149. |
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来源：心理研究所
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