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A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23
文献类型：期刊论文
| 作者 | Li, Yongzhe1,2; Zhang, Kunlin3 ; Chen, Hua1,2; Sun, Fei1,2; Xu, Juanjuan1,2; Wu, Ziyan1,2; Li, Ping1,2; Zhang, Liuyan3; Du, Yang3; Luan, Haixia1,2
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| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 45期号:11页码:1361-+ |
| 英文摘要 | Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjogren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: P-combined = 1.31 x 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjogren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326384100017 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10620]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100021, Peoples R China 2.Chinese Acad Med Sci, Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatol & Immunol, Urumqi, Peoples R China 5.Inner Mongolia Med Coll, Affiliated Hosp, Dept Rheumatol, Hohhot, Peoples R China 6.Zhejiang Univ, Affiliated Hosp 2, Coll Med, Dept Rheumatol, Hangzhou 310027, Zhejiang, Peoples R China 7.Anhui Med Univ, Affiliated Anhui Prov Hosp, Dept Rheumatol & Immun, Hefei, Peoples R China 8.Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China 9.Tianjin Med Univ, Gen Hosp, Dept Immunol, Tianjin, Peoples R China 10.Sun Yat Sen Univ, SUN Yat Sen Mem Hosp, Dept Rheumatol, Guangzhou 510275, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yongzhe,Zhang, Kunlin,Chen, Hua,et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23[J]. NATURE GENETICS,2013,45(11):1361-+. |
| APA | Li, Yongzhe.,Zhang, Kunlin.,Chen, Hua.,Sun, Fei.,Xu, Juanjuan.,...&Zhang, Fengchun.(2013).A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23.NATURE GENETICS,45(11),1361-+. |
| MLA | Li, Yongzhe,et al."A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23".NATURE GENETICS 45.11(2013):1361-+. |
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来源：心理研究所
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