Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats
文献类型：期刊论文
| 作者 | Gao, Jun; Li, Yonghui; Zhu, Ning; Brimijoin, Stephen; Sui, Nan |
| 刊名 | JOURNAL OF PSYCHOPHARMACOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 27期号:2页码:181-191 |
| 关键词 | Abstinence D1-like D2-like dorsolateral caudate-putamen (dlCPu) morphine nucleus accumbens shell (NAshell) seeking self-administration |
| ISSN号 | 0090-6905 |
| 产权排序 | 1 |
| 通讯作者 | Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China. |
| 英文摘要 | Drug-associated cues can elicit relapse to drug seeking after abstinence. Studies with extinction-reinstatement models implicate dopamine (DA) in the nucleus accumbens shell (NAshell) and dorsolateral caudate-putamen (dlCPu) in cocaine seeking. However, less is known about their roles in cue-induced opiate seeking after prolonged abstinence. Using a morphine self-administration and abstinence-relapse model, we explored the roles of NAshell and dlCPu DA and the D1/D2-like receptor mechanisms underlying morphine rewarding and/or seeking. Acquisition of morphine self-administration was examined following 6-Hydroxydopamine hydrobromide (6-OHDA) lesions of the NAshell and dlCPu. For morphine seeking, rats underwent 3 weeks' morphine self-administration followed by 3 weeks' abstinence from morphine and the training environment. Prior to testing, 6-OHDA, D1 antagonist SCH23390, or D2 antagonist eticlopride was locally injected; then rats were exposed to morphine-associated contextual and discrete cues. Results show that acquisition of morphine self-administration was inhibited by NAshell (not dlCPu) lesions, while morphine seeking was attenuated by lesions of either region, by D1 (not D2) receptor blockade in NAshell, or by blockade of either D1 or D2 receptors in dlCPu. These data indicate a critical role of dopaminergic transmission in the NAshell (via D1-like receptors) and dlCPu (via D1- and D2-like receptors) in morphine seeking after prolonged abstinence. |
| 学科主题 | Cognitive neuroscience |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Basic Research Program of China (2009CB522002); Knowledge Innovation Program of Chinese Academy of Sciences (KSCX2-EW-R-12); National Natural Science Foundation Grants of China (31170988); and Chinese Academy of Sciences Visiting Professorships for Senior International Scientists Program (2010T1S13). |
| 原文出处 | http://ac.els-cdn.com/S0924977X11000022/1-s2.0-S0924977X11000022-main.pdf?_tid=e31ba62a-ce08-11e4-ae03-00000aab0f26&acdnat=1426750009_92476d403c6c642882fee8bdd1b4b7ea |
| 语种 | 英语 |
| WOS记录号 | WOS:000313900200008 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10626]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Gao, Jun,Li, Yonghui,Zhu, Ning,et al. Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2013,27(2):181-191. |
| APA | Gao, Jun,Li, Yonghui,Zhu, Ning,Brimijoin, Stephen,&Sui, Nan.(2013).Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats.JOURNAL OF PSYCHOPHARMACOLOGY,27(2),181-191. |
| MLA | Gao, Jun,et al."Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats".JOURNAL OF PSYCHOPHARMACOLOGY 27.2(2013):181-191. |
入库方式： OAI收割
来源：心理研究所
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