Aging-associated excess formaldehyde leads to spatial memory deficits
文献类型：期刊论文
| 作者 | Tong, Zhiqian1,5; Han, Chanshuai1,4; Luo, Wenhong2; Li, Hui2; Luo, Hongjun2; Qiang, Min1,4; Su, Tao1,4; Wu, Beibei1,4; Liu, Ying1 ; Yang, Xu3
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2013-05-09 |
| 卷号 | 3 |
| 英文摘要 | Recent studies show that formaldehyde participates in DNA demethylation/methylation cycle. Emerging evidence identifies that neuronal activity induces global DNA demethylation and re-methylation; and DNA methylation is a critical step for memory formation. These data suggest that endogenous formaldehyde may intrinsically link learning-responsive DNA methylation status and memory formation. Here, we report that during spatial memory formation process, spatial training induces an initial global DNA demethylation and subsequent re-methylation associated with hippocampal formaldehyde elevation then decline to baseline level in Sprague Dawley rats. Scavenging this elevated formaldehyde by formaldehyde-degrading enzyme (FDH), or enhancing DNA demethylation by a DNA demethylating agent, both led to spatial memory deficits by blocking DNA re-methylation in rats. Furthermore, we found that the normal adult rats intrahippocampally injected with excess formaldehyde can imitate the aged-related spatial memory deficits and global DNA methylation decline. These findings indicate that aging-associated excess formaldheyde contributes to cognitive decline during aging. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318572400002 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10627]  |
| 专题 | 心理研究所_脑与认知科学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Shantou Univ, Coll Med, Cent Lab, Shantou 515041, Guangdong, Peoples R China 3.Huazhong Normal Univ, Lab Environm Sci, Wuhan 430079, Peoples R China 4.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China 5.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, Zhiqian,Han, Chanshuai,Luo, Wenhong,et al. Aging-associated excess formaldehyde leads to spatial memory deficits[J]. SCIENTIFIC REPORTS,2013,3. |
| APA | Tong, Zhiqian.,Han, Chanshuai.,Luo, Wenhong.,Li, Hui.,Luo, Hongjun.,...&He, Rongqiao.(2013).Aging-associated excess formaldehyde leads to spatial memory deficits.SCIENTIFIC REPORTS,3. |
| MLA | Tong, Zhiqian,et al."Aging-associated excess formaldehyde leads to spatial memory deficits".SCIENTIFIC REPORTS 3(2013). |
入库方式： OAI收割
来源：心理研究所
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