Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats
文献类型：期刊论文
| 作者 | Li, Chun-Lu1,2 ; Zhu, Ning1; Meng, Xiao-Lu1,2; Li, Yong-Hui1; Sui, Nan1
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| 刊名 | JOURNAL OF PSYCHOPHARMACOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 27期号:9页码:837-844 |
| 关键词 | Morphine naloxone agranular granular insular cortex conditioned place preference conditioned place aversion |
| ISSN号 | 0269-8811 |
| 产权排序 | 1 |
| 通讯作者 | Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China. |
| 英文摘要 | Recent studies have indicated that the insula underlies affective learning. Although affective learning is well-established in the development of opiate addiction, the role of insula in this context remains unclear. To elucidate the organization of opiate-related affective learning within the insular cortex, we reversibly inactivated each of two major subdivisions of the insula in rats and tested the effects of this inactivation on the acquisition of morphine-induced conditioned place preference (CPP) and conditioned place aversion (CPA) induced by naloxone-precipitated acute morphine withdrawal. Results showed that inactivation of the primary interoceptive posterior granular insula (GI), but not that of the high-order anterior agranular insula (AI), disrupted the acquisition of CPP and that both GI and AI inactivation impaired the acquisition of CPA. These data suggest that the insular cortex is involved in positive and negative affective learning related to opiate addiction. In particular, the GI appears to be critical for both forms of affective learning, whereas the AI is crucial for learning associated with negative affects induced by opiate withdrawal. |
| 学科主题 | Physiological psychology/Biological Psychology |
| 收录类别 | SCI |
| 项目简介 | The study was supported by the Chinese Academy of Sciences (KSCX2-EW-R-12), the National Basic Research Program (2009CB522002), the National Natural Science Foundation (31170988, 31200770), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. |
| 原文出处 | http://jop.sagepub.com/content/27/9/837.full.pdf+html |
| 语种 | 英语 |
| WOS记录号 | WOS:000323644300009 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10634]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,et al. Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2013,27(9):837-844. |
| APA | Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,Li, Yong-Hui,&Sui, Nan.(2013).Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats.JOURNAL OF PSYCHOPHARMACOLOGY,27(9),837-844. |
| MLA | Li, Chun-Lu,et al."Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats".JOURNAL OF PSYCHOPHARMACOLOGY 27.9(2013):837-844. |
入库方式： OAI收割
来源：心理研究所
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