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Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear

文献类型：期刊论文

作者Zheng, Xigeng1; Deschaux, Olivier2,3,4; Lavigne, Jennifer4; Nachon, Ophelie2,3; Cleren, Carine5; Moreau, Jean-Luc6; Garcia, Rene2,3,4
刊名NEUROBIOLOGY OF LEARNING AND MEMORY
出版日期2013
卷号101页码:33-38
关键词Conditioned freezing Fear extinction and return Prefrontal electrical stimulation Medial prefrontal cortex Rats
ISSN号1074-7427
产权排序1
通讯作者Garcia, R (reprint author), Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France.
英文摘要We have recently shown that post-extinction exposure of rats to a sub-conditioning procedure (SCP, i.e. retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) or to acute stress provokes reemergence of extinguished fear. Furthermore, this SCP effect can be abolished by high-frequency stimulation (HFS) of the medial prefrontal cortex (mPFC), when applied following the SCP. The aim of the present study was to test whether HFS of the mPK is effective in preventing both SCP-induced and acute stress-provoked fear reemergence. Rats implanted with stimulating electrodes in the mPFC were trained to acquire high levels of freezing to conditioned auditory cue. This fear response was then extinguished. Three weeks later, no spontaneous recovery was observed, but rats exposed to either the SCP or acute stress again exhibited high levels of freezing. HFS of the mPFC, applied before provoking fear reemergence, prevented the effects of SCP, but not acute stress. These data suggest that acute stress may have more impact on functions of the mPFC and/or associated structures than a situational reminder of fear conditioning. (C) 2013 Elsevier Inc. All rights reserved.
学科主题Cognitive neuroscience
收录类别SCI
项目简介This study was supported by University of Nice-Sophia Antipolis (O.D., J.L., O.N., C.C., R.G.), F. Hoffmann-La Roche (J.L.M), and The Chinese Academy of Science The Chinese Academy of Sciences-Key Laboratory of Mental Health, IPCAS (30971057/KSCX2-EW-J-8 to X.Z.). We thank Dr. D Finn for his critical review of this manuscript.
原文出处http://ac.els-cdn.com/S1074742713000063/1-s2.0-S1074742713000063-main.pdf?_tid=abac3a2a-cc72-11e4-9903-00000aab0f02&acdnat=1426575540_4f1ec438d2dc3915d05a4e131d8e9edb
语种英语
WOS记录号WOS:000317088700005
源URL[http://ir.psych.ac.cn/handle/311026/10639]  
专题心理研究所_中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Aix Marseille Univ, Inst Neurosci Timone, UMR7289, F-13385 Marseille, France
3.CNRS, F-13385 Marseille, France
4.Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France
5.Univ Rouen, Lab Neovasc, ERI 28, F-76183 Rouen, France
6.Hoffmann La Roche AG, Div Pharma, Basel, Switzerland
推荐引用方式
GB/T 7714		 Zheng, Xigeng,Deschaux, Olivier,Lavigne, Jennifer,et al. Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2013,101:33-38.
APA Zheng, Xigeng.,Deschaux, Olivier.,Lavigne, Jennifer.,Nachon, Ophelie.,Cleren, Carine.,...&Garcia, Rene.(2013).Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear.NEUROBIOLOGY OF LEARNING AND MEMORY,101,33-38.
MLA Zheng, Xigeng,et al."Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear".NEUROBIOLOGY OF LEARNING AND MEMORY 101(2013):33-38.

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来源：心理研究所

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