Ten-a Affects Fusion of Central Complex Primordia in Drosophila
文献类型：期刊论文
| 作者 | Cheng, Xuebo1,2; Jiang, Huoqing1; Li, Weizhe1; Lv, Hailong1; Gong, Zhefeng1,3; Liu, Li1,4
|
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013-02-20 |
| 卷号 | 8期号:2页码:1-11 |
| 英文摘要 | The central complex of Drosophila melanogaster plays important functions in various behaviors, such as visual and olfactory memory, visual orientation, sleep, and movement control. However little is known about the genes regulating the development of the central complex. Here we report that a mutant gene affecting central complex morphology, cbd (central brain defect), was mapped to ten-a, a type II trans-membrane protein coding gene. Down-regulation of ten-a in pan-neural cells contributed to abnormal morphology of central complex. Over-expression of ten-a by C767-Gal4 was able to partially restore the abnormal central complex morphology in the cbd mutant. Tracking the development of FB primordia revealed that C767-Gal4 labeled interhemispheric junction that separated fan-shaped body precursors at larval stage withdrew to allow the fusion of the precursors. While the C767-Gal4 labeled structure did not withdraw properly and detached from FB primordia, the two fan-shaped body precursors failed to fuse in the cbd mutant. We propose that the withdrawal of C767-Gal4 labeled structure is related to the formation of the fan-shaped body. Our result revealed the function of ten-a in central brain development, and possible cellular mechanism underlying Drosophila fan-shaped body formation. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | INTRACELLULAR DOMAIN ; LOCOMOTOR BEHAVIOR ; SYNAPSE FORMATION ; GLIAL-CELLS ; BRAIN ; MELANOGASTER ; MEMORY ; BODY ; ORGANIZATION ; ARCHITECTURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000315184200221 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10701]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Zhejiang Univ, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China 4.Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xuebo,Jiang, Huoqing,Li, Weizhe,et al. Ten-a Affects Fusion of Central Complex Primordia in Drosophila[J]. PLOS ONE,2013,8(2):1-11. |
| APA | Cheng, Xuebo,Jiang, Huoqing,Li, Weizhe,Lv, Hailong,Gong, Zhefeng,&Liu, Li.(2013).Ten-a Affects Fusion of Central Complex Primordia in Drosophila.PLOS ONE,8(2),1-11. |
| MLA | Cheng, Xuebo,et al."Ten-a Affects Fusion of Central Complex Primordia in Drosophila".PLOS ONE 8.2(2013):1-11. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。