Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference
文献类型：期刊论文
| 作者 | Qi, Keke1,2 ; Wei, Chuguang3; Li, Yonghui1; Sui, Nan1
|
| 刊名 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE
 |
| 出版日期 | 2013 |
| 卷号 | 7 |
| 关键词 | orexin the nucleus accumbens shell morphine CPP stress-induced reinstatement drug priming-induced reinstatement |
| ISSN号 | 1662-5153 |
| 产权排序 | 1 |
| 通讯作者 | Li, YH (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China. |
| 英文摘要 | Orexins are found to participate in mediating stress-induced drug relapse. However, the neuroanatomical basis that orexin transmission modulates stress induced drug seeking remains unknown. The nucleus accumbens shell (NAcSh), best known for its role in appetitive and negative motivation via dopamine receptors, is likely to be the potential important brain area where the orexin system mediates stress-induced drug relapse since the function of dopamine system in the NAcSh can be regulated by orexin transmission. In the present study, amorphine conditioned place preference (CPP) model was used to determine whether the two types of orexin receptors would be involved into footshock-induced and/or drug priming-induced CPP reinstatement differentially. The results showed that blockade of orexin-1 or orexin-2 receptor in the NAcSh significantly attenuated stress-induced morphine CPP reinstatement, but neither of the orexin antagonists had any effect on morphine priming induced reinstatement. These findings indicate that the NAcSh is a brain area through which orexins participate in stress but not drug priming-induced relapse of opioid seeking. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Physiological psychology/Biological Psychology |
| 类目[WOS] | Behavioral Sciences ; Neurosciences |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
| 关键词[WOS] | COCAINE-SEEKING BEHAVIOR ; VENTRAL TEGMENTAL AREA ; MESOLIMBIC DOPAMINE ; RAT-BRAIN ; HYPOTHALAMIC NEUROPEPTIDES ; PREFRONTAL CORTEX ; FEEDING-BEHAVIOR ; SLEEP REGULATION ; REWARD-SEEKING ; NEURONS |
| 收录类别 | SCI |
| 项目简介 | This study was supported by the Chinese Academy of Sciences (KSCX2-EW-R-12, KSCX2-EW-Q-18), the National Basic Research Program (2009CB522002), the National Natural Science Foundation (31070911, 31170988, 31200770), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000325460700001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10709]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Core Facil, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Keke,Wei, Chuguang,Li, Yonghui,et al. Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2013,7. |
| APA | Qi, Keke,Wei, Chuguang,Li, Yonghui,&Sui, Nan.(2013).Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,7. |
| MLA | Qi, Keke,et al."Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 7(2013). |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。