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Accumulated hippocampal formaldehyde induces age-dependent memory decline
文献类型：期刊论文
| 作者 | Tong, Zhiqian1; Han, Chanshuai1; Luo, Wenhong2; Wang, Xiaohui4,5; Li, Hui2; Luo, Hongjun2; Zhou, Jiangning3; Qi, Jinshun4,5; He, Rongqiao6,7 |
| 刊名 | AGE
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 35期号:3页码:583-596 |
| 关键词 | Alzheimer's disease (AD) Aging Endogenous formaldehyde Long-term potentiation (LTP) Long-term memory (LTM) NMDA receptor |
| 英文摘要 | Aging is an important factor in memory decline in aged animals and humans and in Alzheimer's disease and is associated with the impairment of hippocampal long-term potentiation (LTP) and down-regulation of NR1/NR2B expression. Gaseous formaldehyde exposure is known to induce animal memory loss and human cognitive decline; however, it is unclear whether the concentrations of endogenous formaldehyde are elevated in the hippocampus and how excess formaldehyde affects LTP and memory formation during the aging process. In the present study, we report that hippocampal formaldehyde accumulated in memory-deteriorating diseases such as age-related dementia. Spatial memory performance was gradually impaired in normal Sprague-Dawley rats by persistent intraperitoneal injection with formaldehyde. Furthermore, excess formaldehyde treatment suppressed the hippocampal LTP formation by blocking N-methyl-d-aspartate (NMDA) receptor. Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor. Our results indicate that excess endogenous formaldehyde is a critical factor in memory loss in age-related memory-deteriorating diseases. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Geriatrics & Gerontology |
| 研究领域[WOS] | Geriatrics & Gerontology |
| 关键词[WOS] | LONG-TERM POTENTIATION ; NMDA RECEPTOR SUBUNITS ; ALZHEIMERS-DISEASE ; TRANSGENIC MICE ; SYNAPTIC PLASTICITY ; RAT-BRAIN ; IN-VIVO ; ALDEHYDE DEHYDROGENASE ; FRONTAL-CORTEX ; SPINAL-CORD |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318174100006 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10711]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Shantou Univ, Coll Med, Cent Lab, Shantou 515041, Guangdong, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Shanxi Med Univ, Dept Neurobiol, Taiyuan 030001, Peoples R China 5.Shanxi Med Univ, Natl Key Discipline Physiol, Taiyuan 030001, Peoples R China 6.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, Zhiqian,Han, Chanshuai,Luo, Wenhong,et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline[J]. AGE,2013,35(3):583-596. |
| APA | Tong, Zhiqian.,Han, Chanshuai.,Luo, Wenhong.,Wang, Xiaohui.,Li, Hui.,...&He, Rongqiao.(2013).Accumulated hippocampal formaldehyde induces age-dependent memory decline.AGE,35(3),583-596. |
| MLA | Tong, Zhiqian,et al."Accumulated hippocampal formaldehyde induces age-dependent memory decline".AGE 35.3(2013):583-596. |
入库方式： OAI收割
来源：心理研究所
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