The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat
文献类型：期刊论文
| 作者 | Zhang, Rui-Rui ; Zhang, Wen-Cai; Wang, Jin-Yan; Guo, Jian-You
|
| 刊名 | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
 |
| 出版日期 | 2013-05-01 |
| 卷号 | 16期号:4页码:849-856 |
| 关键词 | Placebo analgesia rat rostral anterior cingulate cortex mu-opioid receptor |
| 英文摘要 | Placebo analgesia is one of the most robust and best-studied placebo effects. Recent researches suggest that placebo analgesia activated the m-opioid receptor signalling in the human brain. However, whether other opioid receptors are involved in the placebo analgesia remains unclear. We have previously evoked placebo responses in mice (Guo et al. 2010, 2011) and these mice may serve as a model for investigating placebo analgesia. In the present study, we tried to explore the site of action and types of opioid receptors involved in placebo response. Male Sprague-Dawley rats were trained with 10 mg/kg morphine for 4 d to establish the placebo analgesia model. This placebo analgesia can be blocked by injection of 5 mg/kg dose naloxone or by microinjection with naloxone (1, 3 or 10 mu g/rat) into rostral anterior cingulate cortex (rACC). Then, animals were tested after intra-rACC microinjection of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP, a selective m-opioid receptor antagonist) or naltrindole (NTI, a highly selective delta-opioid receptor antagonist) or nor-binaltorphimine (nor-BNI, a highly selective kappa-opioid receptor antagonist). Our results showed that CTOP, but not NTI or nor-BNI, could reduce the pain threshold in placebo analgesia rats. It may be concluded that rACC is the key brain region involved in placebo analgesia and the opioid placebo analgesia is mediated exclusively through m-opioid receptor in rat. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| 关键词[WOS] | ANTERIOR CINGULATE ; MICE LACKING ; RESPONSES ; MECHANISMS ; PAIN ; CHOLECYSTOKININ ; ACTIVATION ; NEUROTRANSMISSION ; DISSECTION ; DEPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000316991800014 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10715]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Rui-Rui,Zhang, Wen-Cai,Wang, Jin-Yan,et al. The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2013,16(4):849-856. |
| APA | Zhang, Rui-Rui,Zhang, Wen-Cai,Wang, Jin-Yan,&Guo, Jian-You.(2013).The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,16(4),849-856. |
| MLA | Zhang, Rui-Rui,et al."The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 16.4(2013):849-856. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。