Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats
文献类型：期刊论文
| 作者 | Xue, Xiaofang1; Shao, Shuang1; Wang, Weiwen2 ; Shao, Feng1
|
| 刊名 | NEUROPSYCHOBIOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 68期号:4页码:243-249 |
| 关键词 | Maternal and sibling separation Reversal learning Brain-derived neurotrophic factor Medial prefrontal cortex |
| ISSN号 | 0302-282X |
| 产权排序 | 2 |
| 通讯作者 | Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
| 英文摘要 | Aims: Early postnatal maternal and/or sibling separation (MS) can play an important role in the development of psychopathologies during ontogeny. The purpose of the present study is to investigate the effects of repeated MS on the cognitive and brain-derived neurotrophic factor (BDNF) function of rats. Methods: We investigated the effects of repeated MS that lasted 3 h/day during postnatal days 1-21 on spatial learning and reversal learning in Morris water maze tests in male rats. The rats were tested in 4 trials. Moreover, we examined the effects of MS on BDNF protein expression in the medial prefrontal cortex (mPFC), the nucleus accumbens, and the hippocampus via immunohistochemistry measurements. Results: We found that repeated MS modestly disrupted reversal learning performance in the Morris water maze and decreased BDNF protein expression in the mPFC. Conclusion: The present study enhances our understanding of the neurobiological and behavioral consequences of repeated episodes of MS in rats to some degree. (C) 2013 S. Karger AG, Basel |
| WOS标题词 | Science & Technology ; Social Sciences ; Life Sciences & Biomedicine |
| 学科主题 | Physiological psychology/Biological Psychology,Developmental psychology |
| 类目[WOS] | Neurosciences ; Psychiatry ; Psychology |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychiatry ; Psychology |
| 关键词[WOS] | SPRAGUE-DAWLEY RATS ; PREFRONTAL CORTEX ; SOCIAL-ISOLATION ; COGNITIVE FLEXIBILITY ; PREPULSE INHIBITION ; NUCLEUS-ACCUMBENS ; ISOLATION STRESS ; SCHIZOPHRENIA ; DEPRIVATION ; BDNF |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural Science Foundation of China (grant No. 31070910 and 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000328311900008 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10736]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,et al. Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats[J]. NEUROPSYCHOBIOLOGY,2013,68(4):243-249. |
| APA | Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,&Shao, Feng.(2013).Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats.NEUROPSYCHOBIOLOGY,68(4),243-249. |
| MLA | Xue, Xiaofang,et al."Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats".NEUROPSYCHOBIOLOGY 68.4(2013):243-249. |
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来源：心理研究所
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