PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors
文献类型：期刊论文
| 作者 | Wang, Li1 ; Cao, Chengqi1,2; Wang, Richu1,2; Qing, Yulan1,2; Zhang, Jianxin1; Zhang, Xiang Yang3
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| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2013 |
| 卷号 | 150期号:1页码:156-159 |
| 关键词 | PTSD PAC1 receptor Single-nucleotide polymorphism Association study |
| ISSN号 | 0165-0327 |
| 产权排序 | 1 |
| 通讯作者 | Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China. |
| 英文摘要 | Background: Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults. Methods: Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1 rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system. Results: The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women. Limitations: A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument. Conclusions: The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Trauma psychology |
| 类目[WOS] | Clinical Neurology ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychiatry |
| 关键词[WOS] | POSTTRAUMATIC-STRESS-DISORDER ; SEROTONIN TRANSPORTER GENOTYPE ; INDEPENDENT SAMPLES ; 5-FACTOR MODEL ; CHECKLIST ; EXPOSURE ; GENETICS ; VICTIMS ; SUPPORT ; TRAUMA |
| 收录类别 | SCI |
| 项目简介 | This study was supported by the Knowledge Innovation Project of the Chinese Academy of Sciences (No. KSCX2-EW-Q-18), the National Natural Science Foundation of China (No. 31271099 and No. 30900402), the Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences, and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. |
| 原文出处 | http://ac.els-cdn.com/S0165032713000621/1-s2.0-S0165032713000621-main.pdf?_tid=d2f5bf0a-c92c-11e4-8c3b-00000aacb35f&acdnat=1426215688_a309ec32e91bd8f4d3dac4526f6244a7 |
| 语种 | 英语 |
| WOS记录号 | WOS:000322762600024 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10738]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Wang, Li,Cao, Chengqi,Wang, Richu,et al. PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,150(1):156-159. |
| APA | Wang, Li,Cao, Chengqi,Wang, Richu,Qing, Yulan,Zhang, Jianxin,&Zhang, Xiang Yang.(2013).PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors.JOURNAL OF AFFECTIVE DISORDERS,150(1),156-159. |
| MLA | Wang, Li,et al."PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors".JOURNAL OF AFFECTIVE DISORDERS 150.1(2013):156-159. |
入库方式： OAI收割
来源：心理研究所
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