Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra
文献类型：期刊论文
| 作者 | Ruan, Yeping1; Yao, Li1; Zhang, Bingbing1; Zhang, Shuijuan1; Guo, Jianyou2
|
| 刊名 | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2013 |
| 卷号 | 13 |
| 关键词 | Neurotoxin-Nna Anti-inflammatory Antinociceptive Tumor necrosis factor alpha Interleukin 1 beta Nuclear factor kappa B |
| ISSN号 | 1472-6882 |
| 产权排序 | 2 |
| 通讯作者 | Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China. |
| 英文摘要 | Background: Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the alpha- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on the anti-inflammatory effects of NT. Therefore, the anti-inflammatory activity of Neurotoxin-Nna was investigated in this study. Methods: The anti-inflammatory effects of NT were evaluated by measuring its influence on several crucial factors in inflammatory pathways, including total antioxidant activity, antinociceptive effects in vivo, nuclear factor kappa B (NF-kappa B), polymorphonuclear cells (PMN), inducible nitric oxide synthase (iNOS), adhesion molecule (ICAM-1) and tactile hyperalgesia. Results: NT treatment decreased the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta). NT treatment decreased the total antioxidant status (TAOS) and reduced CFA-induced tactile hyperalgesia in a dose-dependent manner. NT significantly inhibited regulation of NF-kappaB activation and the production of IL-1 beta, TNF-.alpha;, iNOS and CAM-1. Moreover, NT suppressed infiltration of PMN. Conclusions: Our results showed that NT reduced CFA-induced tactile hyperalgesia through inhibition inflammatory pathways in experimental inflammatory rats. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Medical psychology |
| 类目[WOS] | Integrative & Complementary Medicine |
| 研究领域[WOS] | Integrative & Complementary Medicine |
| 关键词[WOS] | NITRIC-OXIDE ; INFLAMMATION ; RATS |
| 收录类别 | SCI |
| 项目简介 | This project was supported by NNSF grant (30800301, 31170992, 81102842) and Nature Sciences Foundation of Zhejiang (Y2101127), projects from Key Laboratory of Mental Health, Institute of Psychology and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8). |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680338/pdf/1472-6882-13-86.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000320255300001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10750]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,13. |
| APA | Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,&Guo, Jianyou.(2013).Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,13. |
| MLA | Ruan, Yeping,et al."Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 13(2013). |
入库方式： OAI收割
来源：心理研究所
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