Adolescent social isolation influences cognitive function in adult rats
文献类型：期刊论文
| 作者 | Sheo, Feng1; Han, Xiao1; Sheo, Shuang1; Wang, Weiwen2
|
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2013-04-01 |
| 卷号 | 8期号:11页码:1025-1030 |
| 关键词 | neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophic factor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmental disorders grants-supported paper neuroregeneration |
| 英文摘要 | Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation (isolated housing, 38-51 days of age) and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Cell Biology ; Neurosciences |
| 研究领域[WOS] | Cell Biology ; Neurosciences & Neurology |
| 关键词[WOS] | BDNF MESSENGER-RNA ; NEUROTROPHIC FACTOR ; FEMALE RATS ; DOPAMINERGIC-NEURONS ; RECEPTOR EXPRESSION ; LATENT INHIBITION ; PREFRONTAL CORTEX ; BRAIN ; SCHIZOPHRENIA ; STRESS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318833800008 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10799]  |
| 专题 | 心理研究所_脑与认知科学国家重点实验室 |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sheo, Feng,Han, Xiao,Sheo, Shuang,et al. Adolescent social isolation influences cognitive function in adult rats[J]. NEURAL REGENERATION RESEARCH,2013,8(11):1025-1030. |
| APA | Sheo, Feng,Han, Xiao,Sheo, Shuang,&Wang, Weiwen.(2013).Adolescent social isolation influences cognitive function in adult rats.NEURAL REGENERATION RESEARCH,8(11),1025-1030. |
| MLA | Sheo, Feng,et al."Adolescent social isolation influences cognitive function in adult rats".NEURAL REGENERATION RESEARCH 8.11(2013):1025-1030. |
入库方式： OAI收割
来源：心理研究所
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