Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear
文献类型：期刊论文
| 作者 | Deschaux, Olivier1,2; Zheng, Xigeng3 ; Lavigne, Jennifer1,2; Nachon, Ophelie1,2; Cleren, Carine1,2; Moreau, Jean-Luc4; Garcia, Rene1,2
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| 刊名 | PSYCHOPHARMACOLOGY
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| 出版日期 | 2013 |
| 卷号 | 225期号:1页码:209-216 |
| 关键词 | Conditioned freezing Fear reemergence Stress and extinction memory Antidepressant Rats |
| ISSN号 | 0033-3158 |
| 产权排序 | 3 |
| 通讯作者 | Deschaux, O (reprint author), Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France. |
| 英文摘要 | The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treatment. We sought to examine another potential inducer of fear reemergence, acute stress, in rats and determine whether fluoxetine prevents this phenomenon. Because in previous studies fluoxetine was administered before extinction, we first analyzed its effect on the SCP-associated reemergence of auditory-cued conditioned fear in rats injected after extinction to avoid any interaction between fluoxetine and extinction learning. Next, we used the same protocol but replaced the SCP with acute stress. We found that the SCP and acute stress, which were carried out 3 weeks after fear extinction, similarly provoked the reemergence of extinguished fear in rats injected with vehicle during the 3-week period. In contrast, the animals treated with fluoxetine during this period behaved similarly to those not exposed to an inducer of fear reemergence. Our data establish acute stress as an inducer of fear reemergence. The results provide further support for the hypothesis that fluoxetine interfered with mechanisms that reactivated extinguished fear, even when administered after fear extinction. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Emotional psychology |
| 类目[WOS] | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| 关键词[WOS] | CONDITIONED FEAR ; PREFRONTAL CORTEX ; SPONTANEOUS-RECOVERY ; RETRIEVAL ; ANTIDEPRESSANTS ; HIPPOCAMPAL ; IMPAIRS ; MEMORY ; RATS ; CONSOLIDATION |
| 收录类别 | SCI |
| 项目简介 | This study was supported by F. Hoffmann-La Roche (J.L.M), the University of Nice-Sophia Antipolis (O.D., J.L., O.N., C. C., R. G.), and The Chinese Academy of Science (X.Z.). We thank Michael Arends for reviewing the English style of the manuscript. |
| 语种 | 英语 |
| WOS记录号 | WOS:000313163900018 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10812]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France 2.Univ Aix Marseille 2, CNRS, UMR 7289, Inst Neurosci Timone, F-13385 Marseille, France 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Hoffmann La Roche AG, Div Pharma, Basel, Switzerland |
| 推荐引用方式 GB/T 7714 | Deschaux, Olivier,Zheng, Xigeng,Lavigne, Jennifer,et al. Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear[J]. PSYCHOPHARMACOLOGY,2013,225(1):209-216. |
| APA | Deschaux, Olivier.,Zheng, Xigeng.,Lavigne, Jennifer.,Nachon, Ophelie.,Cleren, Carine.,...&Garcia, Rene.(2013).Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear.PSYCHOPHARMACOLOGY,225(1),209-216. |
| MLA | Deschaux, Olivier,et al."Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear".PSYCHOPHARMACOLOGY 225.1(2013):209-216. |
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来源：心理研究所
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