Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm
文献类型：期刊论文
| 作者 | Feng, Min1,2,3 ; Sui, Nan1; Li, Ming2
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| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 238页码:178-187 |
| 关键词 | Clozapine Conditioned avoidance response Phencyclidine Motor activity Tolerance Contextual control |
| ISSN号 | 0166-4328 |
| 产权排序 | 1 |
| 通讯作者 | Li, M (reprint author), Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA. |
| 英文摘要 | Repeated administration of antipsychotic drugs induces a sensitization-like or tolerance-like effect in many behavioral tasks, including the conditioned avoidance response (CAR) and the phencyclidine (PCP)-induced hyperlocomotion, two rodent models with high predictive validity for antipsychotic activity. This study investigated the impacts of contextual and behavioral variables on the expression of clozapine tolerance using a recently validated across-model transfer paradigm (Zhang and Li, 2012 [1]). Male Sprague-Dawley rats were first repeatedly treated with clozapine (2.5-10.0 mg/kg, sc) in the CAR model or PCP (1.6 mg/kg, sc)-induced hyperlocomotion model for five consecutive days. They were then tested for the expression of clozapine tolerance in another model for another 5 days. Finally, all rats were switched back to the original model and tested again for the expression of clozapine tolerance. When tested in the PCP model, rats previously treated with clozapine in the CAR model did not show an immediate weaker inhibition of PCP-induced hyperlocomotion than those treated with clozapine for the first time, but showed a significantly weaker inhibition over time. In contrast, when tested in the CAR model, rats previously treated with clozapine in the PCP model showed an immediate weaker disruption of avoidance response than those treated with clozapine for the first time, but this weaker effect diminished over time. These results suggest that the expression of clozapine tolerance is strongly modulated by the test environment and/or selected behavioral response. Clozapine tolerance and its situational specificity may be related to the drug's low extrapyramidal motor side effect, its superior therapeutic efficacy and/or emergence of clozapine withdrawal syndrome. (c) 2012 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Abnormal psychology |
| 类目[WOS] | Behavioral Sciences ; Neurosciences |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
| 关键词[WOS] | CONDITIONED AVOIDANCE-RESPONSE ; PHENCYCLIDINE-INDUCED HYPERLOCOMOTION ; IN-VIVO OCCUPANCY ; ANTIPSYCHOTIC-DRUGS ; ANIMAL-MODELS ; SENSITIZATION ; RATS ; HALOPERIDOL ; DOPAMINE ; OLANZAPINE |
| 收录类别 | SCI |
| 项目简介 | This study was funded by the NIMH grant (R01MH085635) to Professor Ming Li. |
| 原文出处 | http://ac.els-cdn.com/S0166432812006481/1-s2.0-S0166432812006481-main.pdf?_tid=462c4030-b19e-11e4-a452-00000aab0f27&acdnat=1423625586_a378e7919eed5633883fc1d0e2f8d911 |
| 语种 | 英语 |
| WOS记录号 | WOS:000314138800023 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10843]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Min,Sui, Nan,Li, Ming. Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm[J]. BEHAVIOURAL BRAIN RESEARCH,2013,238:178-187. |
| APA | Feng, Min,Sui, Nan,&Li, Ming.(2013).Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm.BEHAVIOURAL BRAIN RESEARCH,238,178-187. |
| MLA | Feng, Min,et al."Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm".BEHAVIOURAL BRAIN RESEARCH 238(2013):178-187. |
入库方式： OAI收割
来源：心理研究所
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