Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study
文献类型:期刊论文
作者 | Liu, Chun-Hong1; Li, Feng2; Li, Su-Fang3; Wang, Yong-Jun2; Tie, Chang-Le2; Wu, Hai-Yan3; Zhou, Zhen4; Zhang, Dan5; Dong, Jie1; Yang, Zhi6 |
刊名 | PSYCHIATRY RESEARCH-NEUROIMAGING |
出版日期 | 2012-08-01 |
卷号 | 203期号:2-3页码:175-179 |
ISSN号 | 0925-4927 |
关键词 | Bipolar disorder Resting state fMRI Amplitude of low-frequency fluctuation |
通讯作者 | Yang, Z (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China. |
产权排序 | 5 |
英文摘要 | We examined resting state brain activity in the depressive phase of bipolar disorder (BD) by measuring the amplitude of low-frequency fluctuations (ALFF) in the functional magnetic resonance imaging (fMRI) signal. Unlike functional connectivity, the ALFF approach reflects local properties in specific regions and provides direct information about impaired foci. Groups of 26 patients with BD depression and 26 gender-, age-, and education-matched healthy subjects participated in fMRI scans. We examined group differences in ALFF findings as well as correlations between clinical measurements and ALFF in the regions showing significant group differences. Our results showed that patients with BD depression had significantly increased ALFF in the left insula, the right caudate nucleus, the temporal gyrus, the bilateral inferior frontal gyrus, and the posterior lobe of the cerebellum. They also had decreased ALFF in the left postcentral gyrus, the left parahippocampal gyrus, and the cerebellum. Moderate negative correlations were found between the Hamilton Depression Rating Scale score and ALFF in the left insular cortex in the patient group. These results support a model of BD that involves dysfunction in the prefrontal-limbic networks and associated striatal systems. We also demonstrated the feasibility of ALFF as a technique to investigate persistent cerebral dysfunction in BD. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
学科主题 | Physiological psychology/Biological Psychology,Medical psychology |
收录类别 | SCI |
项目简介 | The authors gratefully acknowledge Beijing Normal University Imaging Center for Brain Research and Prof. Yu-Feng Zang for their contributions in MRI data acquisition. This study was supported by grants from the 11th Five-Year Key Program for Science and Technology Development of China (grant no. 2007BAI17B05), the National Science Foundations of China (NSFC, grant no. 30900366), the Program for Science and Technology of Beijing (grant no. D101107047810001), the National Basic Research Program of China (grant no. 2007CB512300), and the Capital Medical University Fundamental and Clinical Foundations of China (grant no. 10JL63). |
原文出处 | http://ac.els-cdn.com/S0925492712000352/1-s2.0-S0925492712000352-main.pdf?_tid=62c1517c-a52d-11e4-8911-00000aacb360&acdnat=1422257687_2496714b657e3b905cb604b3b39ba88c |
语种 | 英语 |
WOS记录号 | WOS:000323316900009 |
源URL | [http://ir.psych.ac.cn/handle/311026/10858] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
作者单位 | 1.Capital Med Univ, Beijing Anding Hosp, Dept Radiol, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Lab Clin Psychopharmacol, Beijing 100088, Peoples R China 3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 4.Capital Med Univ, Dept Biomed Engn, Beijing 100069, Peoples R China 5.Capital Med Univ, Fu Xing Hosp, Dept Ultrasound, Beijing 100038, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Chun-Hong,Li, Feng,Li, Su-Fang,et al. Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2012,203(2-3):175-179. |
APA | Liu, Chun-Hong.,Li, Feng.,Li, Su-Fang.,Wang, Yong-Jun.,Tie, Chang-Le.,...&Wang, Chuan-Yue.(2012).Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study.PSYCHIATRY RESEARCH-NEUROIMAGING,203(2-3),175-179. |
MLA | Liu, Chun-Hong,et al."Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study".PSYCHIATRY RESEARCH-NEUROIMAGING 203.2-3(2012):175-179. |
入库方式: OAI收割
来源:心理研究所
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