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Deficits in sustaining reward responses in subsyndromal and syndromal major depression

文献类型：期刊论文

作者Liu, Wen-hua2,3,4; Chan, Raymond C. K.1,5; Wang, Ling-zhi6; Huang, Jia1,5; Cheung, Eric F. C.7; Gong, Qi-yong8; Gollan, Jackie K.9
刊名PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
出版日期2011-06-01
卷号35期号:4页码:1045-1052
关键词Anhedonia Depression Reward responses Stress
ISSN号0278-5846
产权排序4,5
通讯作者Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
英文摘要Preliminary findings suggest a reduction in capacity to sustain reward responses in major depression. However, relatively little is known about the stability of reward learning over time and the effect of stress on reward responses in depressed individuals. This study aimed to evaluate sustained behaviour to maximize reward in the context of known reinforcement contingencies and to evaluate the extent to which stress influences such behaviour in clinically depressed patients (n = 43), subsyndromally depressed individuals (n = 43), and healthy controls (n = 44). A probabilistic reward learning task with contingencies known to participants was used to evaluate the change of reward response over time in both 'stress' and 'non-stress' conditions. Stress was induced by salient negative feedback during the task performance. Questionnaires capturing subjective affect were also administered to all participants after completion of the task. Response bias to the stimulus signaling greater reward decreased significantly over time in both subsyndromally and clinically depressed participants, but not in healthy controls. Healthy controls demonstrated a trend of dysfunctional reward processing under the stress condition. Moreover, in the stress condition, the deficit in sustaining behaviour to maximize reward was associated with subjective rating of pleasure in participants with either subsyndromal depression or major depression. These findings suggest that individuals with depression have difficulty sustaining behaviour during a known reinforcement schedule. Participants with anhedonic symptoms are even less likely to sustain behaviour to maximize reward under stress. (C) 2011 Elsevier Inc. All rights reserved.
学科主题Abnormal psychology
收录类别SCI
项目简介This study was supported by the 100-Scholar Plan (16000-3253182) of Sun Yat-Sen University, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, the Project-Oriented Hundred Talents Programme (O7CX031003), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131 & KSCX2-EW-J-8), and the National Basic Research Programme (973 Programme No. 2007CB512302/5), and the National Science Foundation China Outstanding Young Investigator Award (81088001) to Raymond Chan.
原文出处http://ac.els-cdn.com/S0278584611000741/1-s2.0-S0278584611000741-main.pdf?_tid=f340b4e6-ad01-11e4-96b4-00000aacb35e&acdnat=1423118641_6b7b80b574dc229defbdb4f2f607dcbd
语种英语
WOS记录号WOS:000291848000034
源URL[http://ir.psych.ac.cn/handle/311026/11460]  
专题心理研究所_中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Sun Yat Sen Univ, Fac Life Sci, Guangzhou 510275, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Dept Psychol, Guangzhou 510275, Guangdong, Peoples R China
4.Guangzhou Med Coll, Fac Humanities & Social Sci, Guangzhou, Guangdong, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Guangzhou Psychiat Hosp, Dept Clin Psychol, Guangzhou, Guangdong, Peoples R China
7.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
8.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, W China Hosp,W China Sch Med, Chengdu 610064, Peoples R China
9.Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA
推荐引用方式
GB/T 7714		 Liu, Wen-hua,Chan, Raymond C. K.,Wang, Ling-zhi,et al. Deficits in sustaining reward responses in subsyndromal and syndromal major depression[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2011,35(4):1045-1052.
APA Liu, Wen-hua.,Chan, Raymond C. K..,Wang, Ling-zhi.,Huang, Jia.,Cheung, Eric F. C..,...&Gollan, Jackie K..(2011).Deficits in sustaining reward responses in subsyndromal and syndromal major depression.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,35(4),1045-1052.
MLA Liu, Wen-hua,et al."Deficits in sustaining reward responses in subsyndromal and syndromal major depression".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 35.4(2011):1045-1052.

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来源：心理研究所

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