Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm
文献类型：期刊论文
| 作者 | Bai, Yunjing ; Peng, Yonghua; Liang, Jing; Zheng, Xigeng
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| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2012-08-15 |
| 卷号 | 689期号:1-3页码:118-124 |
| 关键词 | Fos Rostral ventral tegmental area Substantia nigra pars reticulata Behavioral sensitization Morphine Escalating-dose |
| ISSN号 | 0014-2999 |
| 产权排序 | 1 |
| 通讯作者 | Zheng, XG (reprint author), Datun Rd A10, Beijing 100101, Peoples R China. |
| 英文摘要 | The transition to addiction often involves a gradual process of escalated drug intake. The purpose of the present study was to characterize neuronal activation in the ventral tegmental area (VTA) and substantia nigra (SN) following chronic escalating-dose morphine exposure (days 1-7, 2 mg/kg/d; days 8-21, beginning at 10 mg/kg/d, increasing by 2 mg/kg/d), with steady-dose morphine (2 mg/kg/d, i.p., for 21 days) as the comparison. Using immunohistochemical double-staining for tyrosine hydroxylase (TH) and Fos, we found that the number of Fos(+)TH(+) neurons in the rostral VTA and number of Fos(+)TH(-) neurons in the lateral SNr were significantly increased in escalating-dose morphine-treated rats compared with steady-dose morphine-treated rats and acute morphine-treated rats. Meanwhile, this increase was associated with robust expression of behavioral sensitization after a challenge with 10 mg/kg morphine. The number of Fos(+)TH(+) neurons was significantly increased by acute morphine in the caudal VTA and SNc, but this number did not increase further with morphine pretreatment. These results demonstrate that behavioral sensitization was associated with elevated activation of dopaminergic neurons in the rostral VTA and nondopaminergic neurons in the lateral SNr, which could only be induced by chronic escalating-dose morphine rather than chronic steady-dose morphine pretreatment. (C) 2012 Elsevier B.V. All rights reserved. |
| 学科主题 | Physiological psychology/Biological Psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Foundation of Natural Science (nos. 30900400, 30971057 and 31000463), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (no. YOCX011S01). |
| 语种 | 英语 |
| WOS记录号 | WOS:000306646900016 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/11466]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Yunjing,Peng, Yonghua,Liang, Jing,et al. Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2012,689(1-3):118-124. |
| APA | Bai, Yunjing,Peng, Yonghua,Liang, Jing,&Zheng, Xigeng.(2012).Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm.EUROPEAN JOURNAL OF PHARMACOLOGY,689(1-3),118-124. |
| MLA | Bai, Yunjing,et al."Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm".EUROPEAN JOURNAL OF PHARMACOLOGY 689.1-3(2012):118-124. |
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来源：心理研究所
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