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Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals

文献类型：期刊论文

作者Mellacqua, Zefiro1; Eyeson, Joanna1; Orr, Ken D.2; Morgan, Kevin D.1; Zanelli, Jolanta1; Lloyd, Tuhina3; Morgan, Craig1; Fearon, Paul1; Hutchinson, Gerard; Doody, Gillian A.
刊名SCHIZOPHRENIA RESEARCH
出版日期2012-12-01
卷号142期号:1-3页码:159-164
关键词Schizophrenia Neurological signs IQ Motor coordination Executive function First episode psychosis Healthy individuals
ISSN号0920-9964
产权排序5
通讯作者Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, PO 40,Crespigny Pk, London SE5 8AF, England.
英文摘要The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are specific to psychosis is essential to inform the pathophysiology of this disorder. We evaluated a large epidemiological sample of patients with first episode psychosis (n = 242) and a population-based sample of healthy individuals (n = 155), as part of the AESOP study. We examined neurological soft signs using the Neurological Evaluation Scale (Buchanan and Heinrichs, 1989), and generalized and specific cognitive deficits (memory; verbal abilities; attention, concentration and mental speed; executive functions and working memory; language; visual constructual/perceptual abilities). In patients, more neurological signs across all subscales were associated with worse general cognitive function, while in controls this was only present for sensory integration and sequencing signs. Furthermore, in patients, but not in healthy individuals, more sensory integrative signs were associated with deficits in specific cognitive domains, such as memory, verbal abilities, language, visual/perceptual, executive function (p ranging <0.001-0.002); sequencing signs with language, executive function, and attention (p<0.001-0.004); and motor signs with poorer verbal abilities (p=0.001). These findings indicate the presence of specific associations between neurological and cognitive deficits in psychosis that are distinct from those of healthy individuals. (C) 2012 Elsevier B.V. All rights reserved.
学科主题Abnormal psychology
收录类别SSCI
项目简介This study was funded by the UK Medical Research Council. We thank the Stanley Medical Research Institute for their support. Paola Dazzan's research is supported by NARSAD and the BIAL Foundation. Raymond Chan is supported by grants from the National Science Fund China Young Investigator Award (81088001), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of psychology.
原文出处http://ac.els-cdn.com/S0920996412005683/1-s2.0-S0920996412005683-main.pdf?_tid=69258af4-ad09-11e4-a3e5-00000aacb360&acdnat=1423121845_c8d47ab4d66d05f08a7f4e0dc534df10
语种英语
WOS记录号WOS:000311220900024
源URL[http://ir.psych.ac.cn/handle/311026/11467]  
专题心理研究所_脑与认知科学国家重点实验室
作者单位1.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London SE5 8AF, England
2.Sir Charles Gairdner Hosp, Dept Psychiat, Perth, WA, Australia
3.Univ Nottingham, Dept Psychiat, Nottingham NG7 2RD, England
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Univ Bristol, Acad Unit Psychiat, Bristol, Avon, England
6.Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England
推荐引用方式
GB/T 7714		 Mellacqua, Zefiro,Eyeson, Joanna,Orr, Ken D.,et al. Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals[J]. SCHIZOPHRENIA RESEARCH,2012,142(1-3):159-164.
APA Mellacqua, Zefiro.,Eyeson, Joanna.,Orr, Ken D..,Morgan, Kevin D..,Zanelli, Jolanta.,...&Dazzan, Paola.(2012).Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals.SCHIZOPHRENIA RESEARCH,142(1-3),159-164.
MLA Mellacqua, Zefiro,et al."Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals".SCHIZOPHRENIA RESEARCH 142.1-3(2012):159-164.

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