Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats
文献类型：期刊论文
| 作者 | Liang, Jing1,2,3 ; Ma, Si-Si1,2; Li, Yi-Jing1,2; Ping, Xing-Jie1,2; Hu, Ling1,2; Cui, Cai-Lian1,2
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| 刊名 | NEUROCHEMICAL RESEARCH
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| 出版日期 | 2012-07-01 |
| 卷号 | 37期号:7页码:1482-1489 |
| 关键词 | Morphine Conditioned place preference (CPP) Dopamine (DA) Tyrosine hydroxylase (TH) |
| ISSN号 | 0364-3190 |
| 产权排序 | 2 |
| 通讯作者 | Cui, CL (reprint author), Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, 38 Xueyuan Rd, Beijing 100083, Peoples R China. |
| 英文摘要 | Our previous study demonstrated that morphine dose- and time-dependently elevated dopamine (DA) concentrations in the nucleus accumbens (NAc) during the expression of morphine-induced conditioned place preference (CPP) in rats. However, still unknown are how DA concentrations dynamically change during the morphine-induced CPP test and whether tyrosine hydroxylase (TH) activity in the ventral tegmental area (VTA) plays a vital role in this process. In the present study, we measured dynamic changes in TH and phosphorylated TH serine 40 (pTH Ser(40)) and pTH Ser(31) proteins in the VTA, and DA concentrations in the NAc at 5 min intervals during a 30 min morphine-induced CPP test. Rats that underwent morphine-induced CPP training significantly preferred the morphine-paired chamber during the CPP expression test, an effect that lasted at least 30 min in the drug-free state. DA concentrations in the NAc markedly increased at 15 min when the rats were returned to the CPP boxes to assess the expression of preference for the previously drug-paired chamber. DA concentrations then declined 2 h after the CPP test. TH and pTH Ser(40) levels, but not pTH Ser(31) levels, in the VTA were enhanced during the CPP test. These results indicated that TH and the phosphorylation of TH Ser(40) in the VTA may be responsible for DA synthesis and release in the NAc during the behavioral expression of conditioned reward elicited by a drug-associated context. |
| 学科主题 | Physiological psychology/Biological Psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by grants from the National Natural Science Foundation (30970933) and National Basic Research Program (2009CB522003). |
| 原文出处 | http://nri.bjmu.edu.cn/english/html/2012publish/1204.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000304878200013 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/11477]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China 2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Jing,Ma, Si-Si,Li, Yi-Jing,et al. Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats[J]. NEUROCHEMICAL RESEARCH,2012,37(7):1482-1489. |
| APA | Liang, Jing,Ma, Si-Si,Li, Yi-Jing,Ping, Xing-Jie,Hu, Ling,&Cui, Cai-Lian.(2012).Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats.NEUROCHEMICAL RESEARCH,37(7),1482-1489. |
| MLA | Liang, Jing,et al."Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats".NEUROCHEMICAL RESEARCH 37.7(2012):1482-1489. |
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来源：心理研究所
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