Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings
文献类型：期刊论文
| 作者 | Zhao, Yan Li1; Tan, Shu Ping1; Yang, Fu De1; Wang, Li Li2; Feng, Wen Feng3; Chan, Raymond C. K.4,5 ; Gao, Xiao6; Zhou, Dong Feng7; Li, Bin Bin1; Song, Chong Sheng1
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| 刊名 | SCHIZOPHRENIA RESEARCH
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| 出版日期 | 2011-12-01 |
| 卷号 | 133期号:1-3页码:112-119 |
| ISSN号 | 0920-9964 |
| 关键词 | Working memory Schizophrenia Event-related potentials Sternberg |
| 通讯作者 | Zou, YZ (reprint author), Beijing Hui Long Guan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China. |
| 产权排序 | 4,5 |
| 英文摘要 | The present study combined a time-locked paradigm and high-time-resolution event-related potential (ERP) recordings to examine different phases of working memory, including early visual processing and late memory-related processes of encoding, maintenance, and retrieval, in 67 adults with schizophrenia and 46 healthy controls. Alterations in ERP components were correlated with task performance. Patients performed significantly worse in the working memory task than healthy subjects, although all subjects' accuracy exceeded 80%. During encoding, the N1 and P2 component amplitudes were lower while the P300 amplitude was higher in schizophrenic patients compared to healthy controls. There were no differences between groups with respect to the mean amplitudes of the negative slow waves in the early stage (the first 400 ms) of the maintenance phase. However, in the next 500-ms time window, the patients exhibited a more negative deflection in the middle fronto-central region than the control group. Likewise, a similar pattern was observed in the second 500-ms period in the middle fronto-central region, although the effect was marginally significant. There were no differences between groups in the remaining 1000 ms. During retrieval, the P1, N1 and P2 amplitudes were lower while the P300 amplitude and latency were higher in schizophrenic patients. The present results indicate early visual deficits in the working memory task in adults with schizophrenia. Impairments in the maintenance phase were confined to the late rehearsal stage. The increased P300 amplitude at the fronto-central electrode sites along with the poorer behavioral performance suggests that schizophrenic patients have an inefficient working memory system. (C) 2011 Elsevier B.V. All rights reserved. |
| 学科主题 | Abnormal psychology |
| 收录类别 | SSCI |
| 项目简介 | This study was partially supported by Beijing Municipal Science & Technology Commission grant (No. D0906001040191), Beijing Natural Science Foundation grant (No. 7102086), Fund of Capital Medical Development and Research grant (No. 2007-3059),and Beijing Municipal Training Programme Foundation for the Talents(No. 2007id0301400101).This work was supported by the major project of Beijing science and technology: D0906001000091. |
| 原文出处 | http://jyxy.suda.edu.cn/teacher/fengwenfeng/wp-content/uploads/2014/10/ZhaoYanliFeng_2011_SchizophreniaResearch.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000298512500018 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/11478]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Beijing Hui Long Guan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 3.Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 6.Southwest Univ, Sch Psychol, Chongqing 400715, Peoples R China 7.Peking Univ, Inst Mental Hlth, Beijing 100091, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yan Li,Tan, Shu Ping,Yang, Fu De,et al. Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings[J]. SCHIZOPHRENIA RESEARCH,2011,133(1-3):112-119. |
| APA | Zhao, Yan Li.,Tan, Shu Ping.,Yang, Fu De.,Wang, Li Li.,Feng, Wen Feng.,...&Zou, Yi Zhuang.(2011).Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings.SCHIZOPHRENIA RESEARCH,133(1-3),112-119. |
| MLA | Zhao, Yan Li,et al."Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings".SCHIZOPHRENIA RESEARCH 133.1-3(2011):112-119. |
入库方式： OAI收割
来源：心理研究所
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