Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats
文献类型：期刊论文
| 作者 | Han, Xiao1; Li, Nanxin1,2; Xue, Xiaofang1; Shao, Feng1; Wang, Weiwen3
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| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2012-04-04 |
| 卷号 | 1447页码:38-43 |
| 关键词 | Adolescence Social isolation Latent inhibition Dopamine D2 receptor Medial prefrontal cortex Nucleus accumbens |
| ISSN号 | 0006-8993 |
| 产权排序 | 3 |
| 通讯作者 | Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
| 英文摘要 | Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of pen-adolescent social isolation on latent inhibition (LI) and dopamine 02 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats were randomly divided into adolescent isolation (ISO; isolated housing, 21-34 days of age) and social housing (SOC) groups. LI was tested at postnatal day 56. After behavioral testing, the number of dopamine D2 receptor-expressing cells was determined using immunohistochemistry. Adolescent social isolation impaired LI and increased the number of cells expressing the D2 receptor in the mPFC and NAc. The results suggest that adolescent social isolation produces profound effects on cognitive and dopaminergic function in adult rats, and could be used as an animal model of various neurodevelopmental disorders. (C) 2012 Elsevier B.V. All rights reserved. |
| 学科主题 | Physiological psychology/Biological Psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural of Science Foundation of China (grant No. 31070910, 30500158), National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), American Psychological Association, and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001). |
| 原文出处 | http://ac.els-cdn.com/S0006899312001618/1-s2.0-S0006899312001618-main.pdf?_tid=d94ecbea-adab-11e4-b847-00000aab0f27&acdnat=1423191612_899144edc20941d6638d49931dbd3307 |
| 语种 | 英语 |
| WOS记录号 | WOS:000303033300005 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/11481]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Xiao,Li, Nanxin,Xue, Xiaofang,et al. Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats[J]. BRAIN RESEARCH,2012,1447:38-43. |
| APA | Han, Xiao,Li, Nanxin,Xue, Xiaofang,Shao, Feng,&Wang, Weiwen.(2012).Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats.BRAIN RESEARCH,1447,38-43. |
| MLA | Han, Xiao,et al."Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats".BRAIN RESEARCH 1447(2012):38-43. |
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来源：心理研究所
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