Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats
文献类型：期刊论文
| 作者 | Li, Xianghong2; Luo, Fei1,2 ; Shi, Lihong3; Woodward, Donald J.4; Chang, Jingyu4
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| 刊名 | NEUROSCIENCE RESEARCH
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| 出版日期 | 2011-10-01 |
| 卷号 | 71期号:2页码:149-160 |
| 关键词 | Striatum Frontal cortex Substantia nigra pars reticulata Globus pallidus Movement initiation Timing |
| ISSN号 | 0168-0102 |
| 产权排序 | 2 |
| 通讯作者 | Luo, F (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China. |
| 英文摘要 | The question pursued in this study was when neural activity appears in the cortico-basal ganglia system that could predict alternate behavioral responses in a reaction time (RT) task. In this protocol, rats first performed a nose poke to initiate a trial, depressed a lever when presented, and then released the lever after a tone cue. Multiple-channel, single-unit recordings (up to 62 units) were obtained simultaneously from the prefrontal cortex, the dorsal medial striatum, the globus pallidus, and the substantia nigra pars reticulata in a single rat during a session. Results indicated that (1) global alterations of neural activity appeared in clusters, which was associated with different behavioral components and observed in each of the targeted areas; (2) small independent subsets of neurons responded differently between error (lever was released before tone presentation) and correct trials (lever was released within 0.5 s after tone onset) during these behavioral episodes; (3) significant correlations between RTs and single units activities were found in the early preparation phases of the task. The results reveal that complex early preparatory activity exists several seconds before the final movements in a RT task, which may determine executive functions leading to rapid decoding of alternate behavioral performances. (C) 2011 Published by Elsevier Ireland Ltd and the Japan Neuroscience Society. |
| 学科主题 | Physiological psychology/Biological Psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the Tourette Syndrome Association, AA-10337, DA-2338, and NS-40628 to D.J. Woodward, DA-10370, NS-43441, and TW-06144 to J.-Y. Chang, and by the National Natural Science Foundation of China (30770688 and 30970959), a Beijing NNSF grant (5082008), the 100 Talented Plan of the Chinese Academy of Sciences, the National Hi-Tech Research and Development Program of China (Grant No. 2008AA022604), and a grant from NIH Fogarty International Center (R03-TW 008038) to F. Luo. |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0168010211001829# |
| 语种 | 英语 |
| WOS记录号 | WOS:000295556600007 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/11499]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China 3.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27103 USA 4.Neurosci Res Inst N Carolina, Winston Salem, NC 27104 USA |
| 推荐引用方式 GB/T 7714 | Li, Xianghong,Luo, Fei,Shi, Lihong,et al. Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats[J]. NEUROSCIENCE RESEARCH,2011,71(2):149-160. |
| APA | Li, Xianghong,Luo, Fei,Shi, Lihong,Woodward, Donald J.,&Chang, Jingyu.(2011).Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats.NEUROSCIENCE RESEARCH,71(2),149-160. |
| MLA | Li, Xianghong,et al."Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats".NEUROSCIENCE RESEARCH 71.2(2011):149-160. |
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