The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
文献类型：期刊论文
| 作者 | Long, Haixia; Liu, Bing; Hou, Bing; Wang, Chao; Li, Jin; Qin, Wen; Wang, Dawei; Zhou, Yuan ; Kendrick, Keith M.; Yu, Chunshui
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| 刊名 | NEUROSCIENCE BULLETIN
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| 出版日期 | 2013 |
| 卷号 | 29期号:1页码:4-15 |
| 关键词 | 5-HTTLPR functional and anatomical connectivity amygdala prefrontal cortex Han Chinese |
| ISSN号 | 0304-3940 |
| 产权排序 | 4 |
| 通讯作者 | Jiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China. |
| 英文摘要 | The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in generelated studies and their potential clinical applications. |
| 学科主题 | Physiological psychology/Biological Psychology,Emotional psychology |
| 收录类别 | SCI |
| 项目简介 | This work was partly supported by the National Key Basic Research and Development Program (973) (2011CB707800), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02030300), the Natural Science Foundation of China (91132301 and 81000582), and the Beijing Nova Program (2010B06). |
| 原文出处 | http://static.springer.com/sgw/documents/1373402/application/pdf/PDF+Article.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000314298300003 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10673]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | Jiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Long, Haixia,Liu, Bing,Hou, Bing,et al. The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala[J]. NEUROSCIENCE BULLETIN,2013,29(1):4-15. |
| APA | Long, Haixia.,Liu, Bing.,Hou, Bing.,Wang, Chao.,Li, Jin.,...&Jiang, Tianzi.(2013).The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala.NEUROSCIENCE BULLETIN,29(1),4-15. |
| MLA | Long, Haixia,et al."The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala".NEUROSCIENCE BULLETIN 29.1(2013):4-15. |
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来源：心理研究所
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