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Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease
文献类型：期刊论文
| 作者 | Wang, Jinhui1; Zuo, Xinian2 ; Dai, Zhengjia1; Xia, Mingrui1; Zhao, Zhilian3; Zhao, Xiaoling4; Jia, Jianping4; Han, Ying4; He, Yong1
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| 刊名 | BIOLOGICAL PSYCHIATRY
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| 出版日期 | 2013 |
| 卷号 | 73期号:5页码:472-481 |
| 关键词 | Connectivity connectomics default-mode MCI modularity small-world |
| ISSN号 | 0006-3223 |
| 产权排序 | 3 |
| 通讯作者 | He, Y (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, 19 Xinjiekouwai St, Beijing 100875, Peoples R China. |
| 英文摘要 | Background: Alzheimer's disease disrupts the topological architecture of whole-brain connectivity (i.e., the connectome); however, whether this disruption is present in amnestic mild cognitive impairment (aMCI), the prodromal stage of Alzheimer's disease, remains largely unknown. Methods: We employed resting-state functional magnetic resonance imaging and graph theory approaches to systematically investigate the topological organization of the functional connectome of 37 patients with aMCI and 47 healthy control subjects. Frequency-dependent brain networks were derived from wavelet-based correlations of both high-and low-resolution parcellation units. Results: In the frequency interval .031-.063 Hz, the aMCI patients showed an overall decreased functional connectivity of their brain connectome compared with control subjects. Further graph theory analyses of this frequency band revealed an increased path length of the connectome in the aMCI group. Moreover, the disease targeted several key nodes predominantly in the default-mode regions and key links primarily in the intramodule connections within the default-mode network and the intermodule connections among different functional systems. Intriguingly, the topological aberrations correlated with the patients' memory performance and differentiated individuals with aMCI from healthy elderly individuals with a sensitivity of 86.5% and a specificity of 85.1%. Finally, we demonstrated a high reproducibility of our findings across different large-scale parcellation schemes and validated the test-retest reliability of our network-based approaches. Conclusions: This study demonstrates a disruption of whole-brain topological organization of the functional connectome in aMCI. Our finding provides novel insights into the pathophysiological mechanism of aMCI and highlights the potential for using connectome-based metrics as a disease biomarker. |
| 学科主题 | Psychology of old age |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the Natural Science Foundation of China (Grant numbers 81030028, 30970823, and 81171409), Beijing Natural Science Foundation (Grant number 7102090, Z111107067311036), and the Startup Foundation for Distinguished Research Professor of Institute of Psychology, Chinese Academy of Sciences (Y0CX492S03, XNZ). |
| 原文出处 | http://ac.els-cdn.com/S0006322312003034/1-s2.0-S0006322312003034-main.pdf?_tid=4158c5cc-ad0e-11e4-89f7-00000aacb35d&acdnat=1423123926_5f49c71d5258945688721204db6eb7b6 |
| 语种 | 英语 |
| WOS记录号 | WOS:000314634900013 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10684]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | 1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Lab Funct Connectome & Dev,Key Lab Behav Sci, Beijing 100101, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jinhui,Zuo, Xinian,Dai, Zhengjia,et al. Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease[J]. BIOLOGICAL PSYCHIATRY,2013,73(5):472-481. |
| APA | Wang, Jinhui.,Zuo, Xinian.,Dai, Zhengjia.,Xia, Mingrui.,Zhao, Zhilian.,...&He, Yong.(2013).Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease.BIOLOGICAL PSYCHIATRY,73(5),472-481. |
| MLA | Wang, Jinhui,et al."Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease".BIOLOGICAL PSYCHIATRY 73.5(2013):472-481. |
入库方式： OAI收割
来源：心理研究所
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