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Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder
文献类型：期刊论文
| 作者 | Di Martino, Adriana; Zuo, Xi-Nian ; Kelly, Clare; Grzadzinski, Rebecca; Mennes, Maarten; Schvarcz, Ariel; Rodman, Jennifer; Lord, Catherine; Castellanos, F. Xavier; Milham, Michael P.
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| 刊名 | BIOLOGICAL PSYCHIATRY
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| 出版日期 | 2013 |
| 卷号 | 74期号:8页码:623-632 |
| 关键词 | ADHD amygdala autism caudate functional connectivity network centrality precuneus resting state fMRI |
| ISSN号 | 0006-3223 |
| 产权排序 | 2 |
| 通讯作者 | Milham, MP (reprint author), Child Mind Inst, Ctr Developing Brain, 445 Pk Ave, New York, NY 10022 USA. |
| 英文摘要 | Background: Individuals with autism spectrum disorders (ASD) often exhibit symptoms of attention-deficit/hyperactivity disorder (ADHD). Across both disorders, observations of distributed functional abnormalities suggest aberrant large-scale brain network connectivity. Yet, common and distinct network correlates of ASD and ADHD remain unidentified. Here, we aimed to examine patterns of dysconnection in school-age children with ASD and ADHD and typically developing children who completed a resting state functional magnetic resonance imaging scan. Methods: We measured voxelwise network centrality, functional connectivity metrics indexing local (degree centrality [DC]) and global (eigenvector centrality) functional relationships across the entire brain connectome, in resting state functional magnetic resonance imaging data from 56 children with ASD, 45 children with ADHD, and 50 typically developing children. A one-way analysis of covariance, with group as fixed factor (whole-brain corrected), was followed by post hoc pairwise comparisons. Results: Cortical and subcortical areas exhibited centrality abnormalities, some common to both ADHD and ASD, such as in precuneus. Others were disorder-specific and included ADHD-related increases in DC in right striatum/pallidum, in contrast with ASD-related increases in bilateral temporolimbic areas. Secondary analyses differentiating children with ASD into those with or without ADHD-like comorbidity (ASD(+) and ASD(-), respectively) revealed that the ASD(+) group shared ADHD-specific abnormalities in basal ganglia. By contrast, centrality increases in temporolimbic areas characterized children with ASD regardless of ADHD-like comorbidity. At the cluster level, eigenvector centrality group patterns were similar to DC. Conclusions: ADHD and ASD are neurodevelopmental disorders with distinct and overlapping clinical presentations. This work provides evidence for both shared and distinct underlying mechanisms at the large-scale network level. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Medical psychology |
| 类目[WOS] | Neurosciences ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychiatry |
| 关键词[WOS] | RESTING-STATE FMRI ; PERVASIVE DEVELOPMENTAL DISORDERS ; DEFICIT HYPERACTIVITY DISORDER ; DEFAULT-MODE NETWORK ; SPECTRUM DISORDERS ; CONNECTIVITY MRI ; HUMAN BRAIN ; PSYCHIATRIC-DISORDERS ; DIAGNOSTIC INTERVIEW ; YOUNG-CHILDREN |
| 收录类别 | SCI |
| 项目简介 | This work was supported by grants from the Brain & Behavior Research Foundation (previously known as National Alliance for Research in Schizophrenia and Affective Disorders) to ADM and National Institute of Mental Health (K23MH087770 to ADM; R01MH081218 to FXC); from the National Institute of Child Health and Human Development (R01HD065282), Autism Speaks, and the Stavros Niarchos Foundation, awarded to FXC; the Leon Levy Foundation awarded to MPM, ADM, and CK; the Natural Science Foundation of China (81171409, 81220108014) and the Chinese Academy of Sciences (KSZD-EW-TZ-002, Y0CX492S03, Y2CX112006) to X-NZ; and gifts from Joseph P. Healey and the Stavros Niarchos Foundation to the Child Mind Institute (MPM). |
| 原文出处 | http://www.researchgate.net/publication/236092943_Shared_and_Distinct_Intrinsic_Functional_Network_Centrality_in_Autism_and_Attention-DeficitHyperactivity_Disorder |
| 语种 | 英语 |
| WOS记录号 | WOS:000324814900010 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/10773]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | Milham, MP (reprint author), Child Mind Inst, Ctr Developing Brain, 445 Pk Ave, New York, NY 10022 USA. |
| 推荐引用方式 GB/T 7714 | Di Martino, Adriana,Zuo, Xi-Nian,Kelly, Clare,et al. Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder[J]. BIOLOGICAL PSYCHIATRY,2013,74(8):623-632. |
| APA | Di Martino, Adriana.,Zuo, Xi-Nian.,Kelly, Clare.,Grzadzinski, Rebecca.,Mennes, Maarten.,...&Milham, Michael P..(2013).Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder.BIOLOGICAL PSYCHIATRY,74(8),623-632. |
| MLA | Di Martino, Adriana,et al."Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder".BIOLOGICAL PSYCHIATRY 74.8(2013):623-632. |
入库方式： OAI收割
来源：心理研究所
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