中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
轻度认知障碍患者视空间功能的fMRI研究

文献类型:期刊论文

作者白静 ; 王荫华 ; 翁旭初 ; 谢晟 ; 黄一宁
刊名中国神经科学杂志
出版日期2003
卷号19期号:5页码:277-281
通讯作者邮箱baijingnv@ sina. com
关键词Alzheimer病 轻度认知障碍 视空间 功能磁共振成像
其他题名Visuospatial dysfunction in mild cognitive impairment: a functional magnetic resonance imaging study
通讯作者王荫华
合作状况国内
中文摘要目的:探索早期诊断Alzheimer病的方法.方法:对轻度认知障碍(MCI)患者和正常对照各9名在fMRI下进行指针位置辨别的视空间功能测试.结果:MCI患者比正常对照的反应时间延长,正确率降低,脑激活图显示MCI患者比正常对照在双侧顶叶,颞枕交界处和视觉皮层的激活强度显著减弱(P<0.05),范围减小,而在右侧额中回的激活代偿性增强.结论:MCI患者视空间功能受损,这可通过fMRI来加以检测.
英文摘要Objective:To contribute to the early diagnosis of Alzheimer disease (AD). Methods: we detected the visuospatial function in the patients with mild cognitive impairment (MCI) using the functional magnetic resonance imaging (fMRI). Nine patients with MCI and nine controls matching in age, gender, level of education and handedness distinguished the analogue clocks with the same location of the hands presented visually while the MR machine was scanning. The raw data of the fMRI were processed with the software AFNI. The reaction time and correct ratio were analyzed by means of independent-samples T test or paired-samples T test with the software Excel. Results:The patients manifested longer reaction time and lower correct ratio than the controls, the brain activation showed less intensity and extension in the patients bilateral parietal lobes,temporal neocortex adjacent to the occipital lobes and the extrastriatal visual cortex except for the right dorsal lateral prefrontal lobe. The activation was prominently in the right hemisphere. Conclusion: The patients with MCI have the deficit in visuospatial function, which can be tested by fMRI.
学科主题医学心理学
收录类别CSCD
原文出处http://d.wanfangdata.com.cn/Periodical_zgsjkxzz200305001.aspx
语种中文
公开日期2014-01-17
源URL[http://ir.psych.ac.cn/handle/311026/9941]  
专题心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
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白静,王荫华,翁旭初,等. 轻度认知障碍患者视空间功能的fMRI研究[J]. 中国神经科学杂志,2003,19(5):277-281.
APA 白静,王荫华,翁旭初,谢晟,&黄一宁.(2003).轻度认知障碍患者视空间功能的fMRI研究.中国神经科学杂志,19(5),277-281.
MLA 白静,et al."轻度认知障碍患者视空间功能的fMRI研究".中国神经科学杂志 19.5(2003):277-281.

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来源:心理研究所

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